Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46987
DC FieldValueLanguage
dc.contributor.authorMaca-Meyer, Nicoleen_US
dc.contributor.authorGonzález, Ana M.en_US
dc.contributor.authorPestano, Joséen_US
dc.contributor.authorFlores, Carlosen_US
dc.contributor.authorLarruga, José M.en_US
dc.contributor.authorCabrera, Vicente M.en_US
dc.contributor.otherPestano Brito, Jose Juan-
dc.date.accessioned2018-11-23T09:57:16Z-
dc.date.available2018-11-23T09:57:16Z-
dc.date.issued2003en_US
dc.identifier.issn1471-2156en_US
dc.identifier.urihttp://hdl.handle.net/10553/46987-
dc.description.abstractBackground: World- wide phylogeographic distribution of human complete mitochondrial DNA sequences suggested a West Asian origin for the autochthonous North African lineage U6. We report here a more detailed analysis of this lineage, unraveling successive expansions that affected not only Africa but neighboring regions such as the Near East, the Iberian Peninsula and the Canary Islands.Results: Divergence times, geographic origin and expansions of the U6 mitochondrial DNA clade, have been deduced from the analysis of 14 complete U6 sequences, and 56 different haplotypes, characterized by hypervariable segment sequences and RFLPs.Conclusions: The most probable origin of the proto- U6 lineage was the Near East. Around 30,000 years ago it spread to North Africa where it represents a signature of regional continuity. Subgroup U6a reflects the first African expansion from the Maghrib returning to the east in Paleolithic times. Derivative clade U6a1 signals a posterior movement from East Africa back to the Maghrib and the Near East. This migration coincides with the probable Afroasiatic linguistic expansion. U6b and U6c clades, restricted to West Africa, had more localized expansions. U6b probably reached the Iberian Peninsula during the Capsian diffusion in North Africa. Two autochthonous derivatives of these clades ( U6b1 and U6c1) indicate the arrival of North African settlers to the Canarian Archipelago in prehistoric times, most probably due to the Saharan desiccation. The absence of these Canarian lineages nowadays in Africa suggests important demographic movements in the western area of this Continent.en_US
dc.languageengen_US
dc.relation.ispartofBMC Geneticsen_US
dc.sourceBMC Genetics[ISSN 1471-2156],v. 4 (15)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject.otherMtdna Variationen_US
dc.subject.otherControl-Regionen_US
dc.subject.otherY-Chromosomeen_US
dc.subject.otherPopulation Historyen_US
dc.subject.otherEuropean Variationen_US
dc.subject.otherSequence Variationen_US
dc.subject.otherIberian Peninsulaen_US
dc.subject.otherGenetic Edgeen_US
dc.subject.otherNear-Easternen_US
dc.subject.otherOriginen_US
dc.titleMitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeographyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2156-4-15en_US
dc.identifier.scopus2442701588-
dc.identifier.isi000186621200001-
dcterms.isPartOfBmc Genetics-
dcterms.sourceBmc Genetics[ISSN 1471-2156],v. 4-
dc.contributor.authorscopusid6603615837-
dc.contributor.authorscopusid57201470100-
dc.contributor.authorscopusid56149756400-
dc.contributor.authorscopusid7103184966-
dc.contributor.authorscopusid6603770287-
dc.contributor.authorscopusid7005213750-
dc.identifier.issue15-
dc.relation.volume4en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000186621200001-
dc.contributor.daisngid1599707-
dc.contributor.daisngid968836-
dc.contributor.daisngid865329-
dc.contributor.daisngid32667-
dc.contributor.daisngid564158-
dc.contributor.daisngid307040-
dc.contributor.daisngid30326284-
dc.identifier.investigatorRIDA-9640-2017-
dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Maca-Meyer, N-
dc.contributor.wosstandardWOS:Gonzalez, AM-
dc.contributor.wosstandardWOS:Pestano, J-
dc.contributor.wosstandardWOS:Flores, C-
dc.contributor.wosstandardWOS:Larruga, JM-
dc.contributor.wosstandardWOS:Cabrera, VM-
dc.date.coverdateOctubre 2003en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePestano Brito, José Juan-
Appears in Collections:Artículos
Show simple item record

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.