Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46984
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dc.contributor.authorCrespillo, Manuelen_US
dc.contributor.authorParedes, Miguel R.en_US
dc.contributor.authorPrieto, Lourdesen_US
dc.contributor.authorMontesino, Martaen_US
dc.contributor.authorSalas, Antonioen_US
dc.contributor.authorAlbarran, Cristinaen_US
dc.contributor.authorV, Álvarez Iglesiasen_US
dc.contributor.authorAmorin, Antonioen_US
dc.contributor.authorBerniell-Lee, Gemmaen_US
dc.contributor.authorBrehm, Antonioen_US
dc.contributor.authorCarril, Juan C.en_US
dc.contributor.authorCorach, Danielen_US
dc.contributor.authorCuevas, Nereaen_US
dc.contributor.authorDi Lonardo, Ana M.en_US
dc.contributor.authorDoutremepuich, Christianen_US
dc.contributor.authorEspinheira, Rosa M.en_US
dc.contributor.authorEspinoza, Martaen_US
dc.contributor.authorGómez, Felixen_US
dc.contributor.authorGonzález, Albertoen_US
dc.contributor.authorHernández, Alexisen_US
dc.contributor.authorHidalgo, M.en_US
dc.contributor.authorJimenez, Magdaen_US
dc.contributor.authorLeite, Fabio P.N.en_US
dc.contributor.authorLópez, Ana M.en_US
dc.contributor.authorLópez-Soto, Manuelen_US
dc.contributor.authorLorente, Jose A.en_US
dc.contributor.authorPagano, Shintiaen_US
dc.contributor.authorPalacio, Ana M.en_US
dc.contributor.authorPestano, José J.en_US
dc.contributor.authorPinheiro, Maria F.en_US
dc.contributor.authorRaimondi, Eduardoen_US
dc.contributor.authorRamón, M. M.en_US
dc.contributor.authorTovar, Florangelen_US
dc.contributor.authorVidal-Rioja, Lidiaen_US
dc.contributor.authorVide, Maria C.en_US
dc.contributor.authorWhittle, Martín R.en_US
dc.contributor.authorYunis, Juan J.en_US
dc.contributor.authorGarcia-Hirschfel, Juliaen_US
dc.contributor.otherSalas, Antonio-
dc.contributor.otherPestano Brito, Jose Juan-
dc.contributor.otherAmorim, Antonio-
dc.contributor.otherLOPEZ PARRA, ANA MARIA-
dc.contributor.otherLORENTE, JOSE A.-
dc.contributor.otherCorach, Daniel-
dc.date.accessioned2018-11-23T09:55:45Z-
dc.date.available2018-11-23T09:55:45Z-
dc.date.issued2006en_US
dc.identifier.issn0379-0738en_US
dc.identifier.urihttp://hdl.handle.net/10553/46984-
dc.description.abstractWe report here a review of the seventh mitochondrial DNA (mtDNA) exercise undertaken by the Spanish and Portuguese working group (GEP) of the International Society for Forensic Genetics (ISFG) corresponding to the period 2003-2004. Five reference bloodstains from five donors (M1-M5), a mixed stain of saliva and semen (M6), and a hair sample (M7) were submitted to each participating laboratory for nuclear DNA (nDNA; autosomal STR and Y-STR) and mtDNA analysis. Laboratories were asked to investigate the contributors of samples M6 and M7 among the reference donors (M1-M5). A total of 34 laboratories reported total or partial mtDNA sequence data from both, the reference bloodstains (M1-M5) and the hair sample (M7) concluding a match between mtDNA profiles of M5 and M7. Autosomal STR and Y-STR profiling was the preferred strategy to investigate the contributors of the semen/saliva mixture (M6). Nuclear DNA profiles were consistent with a mixture of saliva from the donor (female) of M4 and semen from donor M5, being the semen (XY) profile the dominant component of the mixture. Strikingly, and in contradiction to the nuclear DNA analysis, mtDNA sequencing results yield a more simple result: only the saliva contribution (M4) was detected, either after preferential lysis or after complete DNA digestion. Some labs provided with several explanations for this finding and carried out additional experiments to explain this apparent contradictory result. The results pointed to the existence of different relative amounts of nuclear and mtDNAs in saliva and semen. We conclude that this circumstance could strongly influence the interpretation of the mtDNA evidence in unbalanced mixtures and in consequence lead to false exclusions. During the GEP-ISFG annual conference a validation study was planned to progress in the interpretation of mtDNA from different mixtures.en_US
dc.languageengen_US
dc.relation.ispartofForensic Science Internationalen_US
dc.sourceForensic Science International [ISSN 0379-0738],v. 160, p. 157-167en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject3203 Medicina forenseen_US
dc.subject.otherMithocondrial DNAen_US
dc.subject.otherSemenen_US
dc.subject.otherSalivaen_US
dc.titleResults of the 2003-2004 GEP-ISFG collaborative study on mitochondrial DNA: Focus on the mtDNA profile of a mixed semen-saliva stainen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.forsciint.2005.09.005en_US
dc.identifier.scopus33745956778-
dc.identifier.isi000239468600010-
dcterms.isPartOfForensic Science International-
dcterms.sourceForensic Science International[ISSN 0379-0738],v. 160 (2-3), p. 157-167-
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dc.description.lastpage167en_US
dc.description.firstpage157en_US
dc.relation.volume160en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000239468600010-
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dc.identifier.investigatorRIDE-3977-2012-
dc.identifier.investigatorRIDA-9640-2017-
dc.identifier.investigatorRIDA-7938-2008-
dc.identifier.investigatorRIDL-1911-2014-
dc.identifier.investigatorRIDNo ID-
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dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.date.coverdateJulioen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,397-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePestano Brito, José Juan-
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