Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46973
DC FieldValueLanguage
dc.contributor.authorValerón, Pilar F.en_US
dc.contributor.authorPestano, José J.en_US
dc.contributor.authorLuzardo, Octavio P.en_US
dc.contributor.authorZumbado, Manuel L.en_US
dc.contributor.authorAlmeida González, Maira Del Pinoen_US
dc.contributor.authorBoada, Luis D.en_US
dc.contributor.otherDominguez-Boada, Luis-
dc.contributor.otherPestano Brito, Jose Juan-
dc.contributor.otherZumbado, Manuel-
dc.contributor.otherP. Luzardo, Octavio-
dc.date.accessioned2018-11-23T09:50:23Z-
dc.date.available2018-11-23T09:50:23Z-
dc.date.issued2009en_US
dc.identifier.issn0009-2797en_US
dc.identifier.urihttp://hdl.handle.net/10553/46973-
dc.description.abstractOrganochlorine pesticides (OCs) have been associated with breast cancer development and progression. However. the deleterious mechanisms exerted by these contaminants are yet unclear and need to be further elucidated. In the present study, we investigated the effects of a number of OCs (previously detected in human serum from a Spanish population), individually or in combination, on normal human mammary epithelial cells (HMEC) at concentrations close to those found in human beings. The results obtained after a 96-h exposure indicated that OCs exert a clear cytotoxic effect on these cells at higher concentrations than those found in human beings. DDT-derivative organochlorines (DDT and its metabolites, DDE and DDD) are individually more cytotoxic than non-DDT-derivative organochlorines (aldrin and dieldrin). On the contrary, combinations of non-DDT organochlorines were clearly more cytotoxic than combinations of DDT-derivative organochlorines at concentrations close to those described in human serum. Additionally, transcriptional regulation arrays showed that the exposure of HMEC to an environmentally relevant mixture of OCs (p,p'-DDD plus p,p'-DDE plus o,p'-DDE plus aldrin plus dieldrin) sharply upregulated the expression of a number of protein kinases genes, such as ACVRL1, ALK-1, KIT, ERBB3, and ALK-1 at concentrations close to those detected in human populations. Taken together, these findings show a detrimental effect of OCs on human breast cells and indicate a possible association between exposure to organochlorine pesticide combinations and the induction of transformation processes in human breast cells.en_US
dc.languageengen_US
dc.relation.ispartofChemico-biological interactions (Print)en_US
dc.sourceChemico-Biological Interactions[ISSN 0009-2797],v. 180, p. 485-491en_US
dc.subject32 Ciencias médicasen_US
dc.subject320713 Oncologíaen_US
dc.subject2391 Química ambientalen_US
dc.subject.otherBreast-Canceren_US
dc.subject.otherSerum-Levelsen_US
dc.subject.otherC-Kiten_US
dc.subject.otherActivationen_US
dc.subject.otherEstrogensen_US
dc.subject.otherDdten_US
dc.subject.otherXenoestrogensen_US
dc.subject.otherExpressionen_US
dc.subject.otherPollutantsen_US
dc.subject.otherRadiationen_US
dc.titleDifferential effects exerted on human mammary epithelial cells by environmentally relevant organochlorine pesticides either individually or in combinationen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cbi.2009.04.010en_US
dc.identifier.scopus67349150429-
dc.identifier.isi000268077400022-
dcterms.isPartOfChemico-Biological Interactions-
dcterms.sourceChemico-Biological Interactions[ISSN 0009-2797],v. 180 (3), p. 485-491-
dc.contributor.authorscopusid6603469417-
dc.contributor.authorscopusid56149756400-
dc.contributor.authorscopusid6507534124-
dc.contributor.authorscopusid6603459604-
dc.contributor.authorscopusid26533827100-
dc.contributor.authorscopusid6603916807-
dc.description.lastpage491en_US
dc.description.firstpage485en_US
dc.relation.volume180en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000268077400022-
dc.contributor.daisngid1146740-
dc.contributor.daisngid865329-
dc.contributor.daisngid418704-
dc.contributor.daisngid418822-
dc.contributor.daisngid9059452-
dc.contributor.daisngid697526-
dc.identifier.investigatorRIDL-5577-2015-
dc.identifier.investigatorRIDA-9640-2017-
dc.identifier.investigatorRIDB-4495-2010-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages7en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Valeron, PF-
dc.contributor.wosstandardWOS:Pestano, JJ-
dc.contributor.wosstandardWOS:Luzardo, OP-
dc.contributor.wosstandardWOS:Zumbado, ML-
dc.contributor.wosstandardWOS:Almeida, M-
dc.contributor.wosstandardWOS:Boada, LD-
dc.date.coverdateAgosto 2009en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr2,457-
dc.description.jcrqQ2-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptBioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0003-2410-4659-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFernández Valerón, Josefa Pilar-
crisitem.author.fullNamePestano Brito, José Juan-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameAlmeida González, Maira Del Pino-
crisitem.author.fullNameDomínguez Boada, Luis María-
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