Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46962
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dc.contributor.authorBekada, Asmahanen_US
dc.contributor.authorFregel, Rosaen_US
dc.contributor.authorCabrera, Vicente M.en_US
dc.contributor.authorLarruga, José M.en_US
dc.contributor.authorPestano, Joseen_US
dc.contributor.authorBenhamamouch, Sorayaen_US
dc.contributor.authorGonzález, Ana M.en_US
dc.contributor.otherFregel, Rosa-
dc.contributor.otherPestano Brito, Jose Juan-
dc.date.accessioned2018-11-23T09:45:13Z-
dc.date.available2018-11-23T09:45:13Z-
dc.date.issued2013en_US
dc.identifier.issn1932-6203en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/46962-
dc.description.abstractNorth Africa is considered a distinct geographic and ethnic entity within Africa. Although modern humans originated in this Continent, studies of mitochondrial DNA (mtDNA) and Y-chromosome genealogical markers provide evidence that the North African gene pool has been shaped by the back-migration of several Eurasian lineages in Paleolithic and Neolithic times. More recent influences from sub-Saharan Africa and Mediterranean Europe are also evident. The presence of East-West and North-South haplogroup frequency gradients strongly reinforces the genetic complexity of this region. However, this genetic scenario is beset with a notable gap, which is the lack of consistent information for Algeria, the largest country in the Maghreb. To fill this gap, we analyzed a sample of 240 unrelated subjects from a northwest Algeria cosmopolitan population using mtDNA sequences and Y-chromosome biallelic polymorphisms, focusing on the fine dissection of haplogroups E and R, which are the most prevalent in North Africa and Europe respectively. The Eurasian component in Algeria reached 80% for mtDNA and 90% for Y-chromosome. However, within them, the North African genetic component for mtDNA (U6 and M1; 20%) is significantly smaller than the paternal (E-M81 and E-V65; 70%). The unexpected presence of the European-derived Y-chromosome lineages R-M412, R-S116, R-U152 and R-M529 in Algeria and the rest of the Maghreb could be the counterparts of the mtDNA H1, H3 and V subgroups, pointing to direct maritime contacts between the European and North African sides of the western Mediterranean. Female influx of sub-Saharan Africans into Algeria (20%) is also significantly greater than the male (10%). In spite of these sexual asymmetries, the Algerian uniparental profiles faithfully correlate between each other and with the geography.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.sourcePLoS ONE [EISSN 1932-6203], v. 8 (2), (Febrero 2013)en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject.otherHigh-Resolution Analysisen_US
dc.subject.otherMtdna Haplogroup-Hen_US
dc.subject.otherSub-Saharan Africaen_US
dc.subject.otherNear-Easternen_US
dc.subject.otherGenetic-Structureen_US
dc.subject.otherMolecular Dissectionen_US
dc.subject.otherPopulation-Structureen_US
dc.subject.otherPhylogenetic Treeen_US
dc.subject.otherWesternen_US
dc.subject.otherSequenceen_US
dc.titleIntroducing the Algerian Mitochondrial DNA and Y-Chromosome Profiles into the North African Landscapeen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0056775en_US
dc.identifier.scopus2-s2.0-84874211836-
dc.identifier.isi000315182800035-
dcterms.isPartOfPlos One-
dcterms.sourcePlos One[ISSN 1932-6203],v. 8 (2)-
dc.contributor.authorscopusid19638243100-
dc.contributor.authorscopusid8895291800-
dc.contributor.authorscopusid7005213750-
dc.contributor.authorscopusid6603770287-
dc.contributor.authorscopusid56149756400-
dc.contributor.authorscopusid6603267505-
dc.contributor.authorscopusid57201470100-
dc.identifier.eissn1932-6203-
dc.identifier.issuee56775-
dc.relation.volume8en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000315182800035-
dc.contributor.daisngid4180100-
dc.contributor.daisngid1161749-
dc.contributor.daisngid307040-
dc.contributor.daisngid30326284-
dc.contributor.daisngid564158-
dc.contributor.daisngid865329-
dc.contributor.daisngid1745877-
dc.contributor.daisngid263261-
dc.contributor.daisngid968836-
dc.identifier.investigatorRIDH-4942-2015-
dc.identifier.investigatorRIDA-9640-2017-
dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Bekada, A-
dc.contributor.wosstandardWOS:Fregel, R-
dc.contributor.wosstandardWOS:Cabrera, VM-
dc.contributor.wosstandardWOS:Larruga, JM-
dc.contributor.wosstandardWOS:Pestano, J-
dc.contributor.wosstandardWOS:Benhamamouch, S-
dc.contributor.wosstandardWOS:Gonzalez, AM-
dc.date.coverdateFebrero 2013en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,74
dc.description.jcr3,534
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.erihplusERIH PLUS
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePestano Brito, José Juan-
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