Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46679
DC FieldValueLanguage
dc.contributor.authorRodriguez De Castro, F.en_US
dc.contributor.authorAcosta, O.en_US
dc.contributor.authorJulia-Serda, G.en_US
dc.contributor.authorCaminero Luna, José Antonioen_US
dc.contributor.authorCabrera, P.en_US
dc.contributor.authorCarrillo, T.en_US
dc.contributor.authorMolero, T.en_US
dc.date.accessioned2018-11-23T07:00:50Z-
dc.date.available2018-11-23T07:00:50Z-
dc.date.issued1994en_US
dc.identifier.issn0040-6376en_US
dc.identifier.urihttp://hdl.handle.net/10553/46679-
dc.description.abstractBackground - Aneuploidy appears to be a highly specific marker for cancer, and measurement of cellular DNA content by flow cytometry is rapid and reliable. This study was undertaken to determine if the addition of DNA analysis improved the sensitivity of cytological diagnosis of malignancy in pleural fluid.Methods - Pleural effusions from 92 patients were studied by cytological examination and flow cytometry.Results - In 41 patients the final diagnosis was malignancy, there were 40 cases of benign effusions including 22 with pleural tuberculosis, and in the remaining 11 patients with biopsy proven cancer the presence of malignant cells was not found by cytological and histological means in the pleural fluid. Aneuploidy and cytological malignancy were found in 14 samples. There were seven cases with abnormal flow cytometry and negative cytological results. In 12 patients the cytological test results were positive but DNA analysis was normal. Thirty six samples of fluid were both diploid and cytologically negative. Of the 22 tuberculous effusions seven contained aneuploid cells. The sensitivity of DNA and cytological analysis was 51.2% and 63.4%, respectively. The specificity of DNA analysis was 74.5%.Conclusions - DNA analysis of cells in malignant pleural effusions is both less sensitive and specific than the cytological diagnosis. Flow cytometric analysis is not recommended for routine use in the diagnosis of pleural effusions.en_US
dc.languageengen_US
dc.relation.ispartofThoraxen_US
dc.sourceThorax [ISSN 0040-6376],v. 49, p. 692-694en_US
dc.subject32 Ciencias médicasen_US
dc.subject3205 Medicina internaen_US
dc.subject.otherBody Cavity Fluidsen_US
dc.subject.otherFlow-Cytometryen_US
dc.subject.otherPathologyen_US
dc.titleValue of DNA analysis in addition to cytological testing in the diagnosis of malignant pleural effusionsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/thx.49.7.692en_US
dc.identifier.scopus0028243725-
dc.identifier.isiA1994NX31900016-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid57197979109-
dc.contributor.authorscopusid6603171553-
dc.contributor.authorscopusid57188992735-
dc.contributor.authorscopusid7003423561-
dc.contributor.authorscopusid7003526269-
dc.contributor.authorscopusid56294842200-
dc.description.lastpage694en_US
dc.description.firstpage692en_US
dc.relation.volume49en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid464249-
dc.contributor.daisngid3898371-
dc.contributor.daisngid8979056-
dc.contributor.daisngid2942583-
dc.contributor.daisngid285990-
dc.contributor.daisngid4723789-
dc.contributor.daisngid30345863-
dc.description.numberofpages3en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:DECASTRO, FR-
dc.contributor.wosstandardWOS:MOLERO, T-
dc.contributor.wosstandardWOS:ACOSTA, O-
dc.contributor.wosstandardWOS:JULIASERDA, G-
dc.contributor.wosstandardWOS:CAMINERO, J-
dc.contributor.wosstandardWOS:CABRERA, P-
dc.contributor.wosstandardWOS:CARRILLO, T-
dc.date.coverdateEnero 1994en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-6812-2739-
crisitem.author.orcid0000-0002-2931-9483-
crisitem.author.orcid0000-0002-3047-8908-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
crisitem.author.fullNameCaminero Luna, José Antonio-
crisitem.author.fullNameCarrillo Díaz, Teresa-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

17
checked on Jun 16, 2024

WEB OF SCIENCETM
Citations

13
checked on Jun 16, 2024

Page view(s)

77
checked on Apr 13, 2024

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.