Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/46662
Campo DC Valoridioma
dc.contributor.authorCaminero, J. A.en_US
dc.contributor.authorPavón, J. M.en_US
dc.contributor.authorRodríguez De Castro, F.en_US
dc.contributor.authorDíaz, F.en_US
dc.contributor.authorJulià, G.en_US
dc.contributor.authorCaylá, J. A.en_US
dc.contributor.authorCabrera, P.en_US
dc.date.accessioned2018-11-23T06:52:27Z-
dc.date.available2018-11-23T06:52:27Z-
dc.date.issued1996en_US
dc.identifier.issn0040-6376en_US
dc.identifier.urihttp://hdl.handle.net/10553/46662-
dc.description.abstractBackground - Although a priority for tuberculosis control is to achieve the maximum cure rate, compliance with chemotherapy in specific high risk groups (homeless, intravenous drug abusers, chronic alcoholics) is usually poor.Methods - From January 1990 to December 1994 102 patients with tuberculosis (96 pulmonary, six extrapulmonary) who were poorly compliant with treatment were treated with a six month fully intermittent (twice weekly) directly observed regimen. They comprised 71 homeless subjects, 50 chronic alcoholics, 23 intravenous drug abusers, nine infected with HIV, and 11 who had previously abandoned a daily antituberculosis regimen; 53 had more than one of these risk factors. Treatment included isoniazid and rifampicin for six months and pyrazinamide during the first two months. Patients who failed to take their medication on two consecutive occasions were actively sought by telephone or by personal search.Results - After two months of treatment 95 of the 102 patients had taken their medication regularly and 90 of them had negative cultures. Four of the remaining patients had negative cultures after three months. At the end of the six months 87 patients had completed treatment and were considered cured. Only 15 patients abandoned the treatment (13 of whom had more than one risk factor). Only three relapses occurred in the 102 patients at one year follow up and in the 88 patients followed for two years. Two patients required a change of treatment due to major side effects. Although intravenous drug abuse was the only predictor of noncompliance in the multivariate analysis, if the available variables in the second month of treatment were analysed, current poor compliance and abandonment of treatment in the past were found to be significantly associated with non-compliance.Conclusions - This study shows the efficacy of this intermittent regimen and the effectiveness of a directly observed treatment programme.en_US
dc.languageengen_US
dc.relation.ispartofThoraxen_US
dc.sourceThorax[ISSN 0040-6376],v. 51, p. 1130-1133en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherCase reporten_US
dc.subject.otherPulmonary tuberculosisen_US
dc.subject.otherChemotherapyen_US
dc.subject.otherProgramen_US
dc.titleEvaluation of a directly observed six month fully intermittent treatment regimen for tuberculosis in patients suspected of poor complianceen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/thx.51.11.1130en_US
dc.identifier.scopus0029658088-
dc.identifier.isiA1996VU40100015-
dc.contributor.authorscopusid57188992735-
dc.contributor.authorscopusid57197163928-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid7202814257-
dc.contributor.authorscopusid6508111788-
dc.contributor.authorscopusid26425617000-
dc.contributor.authorscopusid7003423561-
dc.description.lastpage1133en_US
dc.description.firstpage1130en_US
dc.relation.volume51en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid285990-
dc.contributor.daisngid1184802-
dc.contributor.daisngid464249-
dc.contributor.daisngid30495115-
dc.contributor.daisngid10024433-
dc.contributor.daisngid42255-
dc.contributor.daisngid4723789-
dc.description.numberofpages4en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Caminero, JA-
dc.contributor.wosstandardWOS:Pavon, JM-
dc.contributor.wosstandardWOS:deCastro, FR-
dc.contributor.wosstandardWOS:Diaz, F-
dc.contributor.wosstandardWOS:Julia, G-
dc.contributor.wosstandardWOS:Cayla, JA-
dc.contributor.wosstandardWOS:Cabrera, P-
dc.date.coverdateEnero 1996en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-6812-2739-
crisitem.author.orcid0000-0001-7874-6636-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePavón Monzo, José Manuel Vicente-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
crisitem.author.fullNameDíaz Reyes, Felipe-
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