Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46620
DC FieldValueLanguage
dc.contributor.authorPena, M. J.en_US
dc.contributor.authorCaminero, J. A.en_US
dc.contributor.authorCampos-Herrero, M. I.en_US
dc.contributor.authorRodríguez-Gallego, J. C.en_US
dc.contributor.authorGarcía-Laorden, M. I.en_US
dc.contributor.authorCabrera, P.en_US
dc.contributor.authorTorres, M. J.en_US
dc.contributor.authorLafarga, B.en_US
dc.contributor.authorRodríguez De Castro, F.en_US
dc.contributor.authorSamper, S.en_US
dc.contributor.authorCañas, F.en_US
dc.contributor.authorEnarson, D. A.en_US
dc.contributor.authorMartín, C.en_US
dc.date.accessioned2018-11-23T06:26:56Z-
dc.date.available2018-11-23T06:26:56Z-
dc.date.issued2003en_US
dc.identifier.issn0040-6376en_US
dc.identifier.urihttp://hdl.handle.net/10553/46620-
dc.description.abstractBackground: In recent years several population based studies using restriction fragment length polymorphism (RFLP) analysis have shown a higher rate of recent transmission of tuberculosis than previously thought. This study was undertaken to determine the transmission patterns of tuberculosis and the potential causes of recent transmission on the island of Gran Canaria (Spain). Methods: The strains of all patients diagnosed with tuberculosis confirmed by culture between 1 January 1993 and 31 December 1996 were typed by RFLP using the insertion sequence IS6110. A cluster was defined as two or more isolates with an identical RFLP pattern. Epidemiological linkage through contact tracing was investigated. Results: Of the total of 719 patients, 153 (21.3%) were excluded because there was inadequate bacterial DNA for genotyping (n=129) or the isolates of Mycobacterium tuberculosis had less than five copies of IS6110 (n=24). The isolates from 409 patients (72.3%) were grouped into 78 different clusters with an estimated 58.5% of the cases being due to recent transmission. Young age was the only significant predictor of clustering. Only in 147 (35.9%) of the 409 patients belonging to a cluster could an epidemiological link be found. 111 patients (19.6%) were identified as having had previous contact with a tuberculosis patient and 81 of them (72.9%) belonged to a cluster. The three largest clusters included 75, 49 and 20 patients, respectively. Conclusion: Recent transmission is frequent among patients with tuberculosis on Gran Canaria and could be associated with certain aspects of control measures. Some of the clusters described in the study could be due to the prevalence of particular strains of M tuberculosis on the island.en_US
dc.languageengen_US
dc.relation.ispartofThoraxen_US
dc.sourceThorax[ISSN 0040-6376],v. 58, p. 618-622en_US
dc.subject32 Ciencias médicasen_US
dc.subject320505 Enfermedades infecciosasen_US
dc.subject3202 Epidemologiaen_US
dc.subject.otherTuberculosisen_US
dc.subject.otherEstudio poblacionalen_US
dc.subject.otherGran Canariaen_US
dc.titleEpidemiology of tuberculosis on Gran Canaria: A 4 year population study using traditional and molecular approachesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/thorax.58.7.618en_US
dc.identifier.scopus2-s2.0-0037677446-
dc.contributor.authorscopusid7101969201-
dc.contributor.authorscopusid57188992735-
dc.contributor.authorscopusid6603084722-
dc.contributor.authorscopusid6506284420-
dc.contributor.authorscopusid6506073949-
dc.contributor.authorscopusid7003423561-
dc.contributor.authorscopusid7402581238-
dc.contributor.authorscopusid7004080248-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid55900454800-
dc.contributor.authorscopusid36824916000-
dc.contributor.authorscopusid7005544905-
dc.contributor.authorscopusid7405842809-
dc.description.lastpage622en_US
dc.description.firstpage618en_US
dc.relation.volume58en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages5en_US
dc.utils.revisionen_US
dc.date.coverdateMarzoen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr4,188
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-1310-3354-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCampos Herrero Navas, María Isolina-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

25
checked on Sep 19, 2021

Page view(s)

26
checked on Sep 11, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.