Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46615
DC FieldValueLanguage
dc.contributor.authorMenéndez, R.en_US
dc.contributor.authorTorres, A.en_US
dc.contributor.authorZalacaín, R.en_US
dc.contributor.authorAspa, J.en_US
dc.contributor.authorMartín Villasclaras, J. J.en_US
dc.contributor.authorBorderías, L.en_US
dc.contributor.authorBenítez Moya, J. M.en_US
dc.contributor.authorRuiz-Manzano, J.en_US
dc.contributor.authorRodríguez De Castro, F.en_US
dc.contributor.authorBlanquer, J.en_US
dc.contributor.authorPérez, D.en_US
dc.contributor.authorPuzo, C.en_US
dc.contributor.authorSánchez Gascón, F.en_US
dc.contributor.authorGallardo, J.en_US
dc.contributor.authorÁlvarez, C.en_US
dc.contributor.authorMolinos, L.en_US
dc.date.accessioned2018-11-23T06:22:58Z-
dc.date.available2018-11-23T06:22:58Z-
dc.date.issued2004en_US
dc.identifier.issn0040-6376en_US
dc.identifier.urihttp://hdl.handle.net/10553/46615-
dc.description.abstractBackground: An inadequate response to initial empirical treatment of community acquired pneumonia (CAP) represents a challenge for clinicians and requires early identification and intervention. A study was undertaken to quantify the incidence of failure of empirical treatment in CAP, to identify risk factors for treatment failure, and to determine the implications of treatment failure on the outcome. Methods: A prospective multicentre cohort study was performed in 1424 hospitalised patients from 15 hospitals. Early treatment failure (,72 hours), late treatment failure, and in-hospital mortality were recorded. Results: Treatment failure occurred in 215 patients (15.1%): 134 early failure (62.3%) and 81 late failure (37.7%). The causes were infectious in 86 patients (40%), non-infectious in 34 (15.8%), and undetermined in 95. The independent risk factors associated with treatment failure in a stepwise logistic regression analysis were liver disease, pneumonia risk class, leucopenia, multilobar CAP, pleural effusion, and radiological signs of cavitation. Independent factors associated with a lower risk of treatment failure were influenza vaccination, initial treatment with fluoroquinolones, and chronic obstructive pulmonary disease (COPD). Mortality was significantly higher in patients with treatment failure (25% v 2%). Failure of empirical treatment increased the mortality of CAP 11-fold after adjustment for risk class. Conclusions: Although these findings need to be confirmed by randomised studies, they suggest possible interventions to decrease mortality due to CAP.en_US
dc.languageengen_US
dc.relation.ispartofThoraxen_US
dc.sourceThorax[ISSN 0040-6376],v. 59, p. 960-965en_US
dc.subject32 Ciencias médicasen_US
dc.subject320505 Enfermedades infecciosasen_US
dc.subject320508 Enfermedades pulmonaresen_US
dc.subject.otherRisk factorsen_US
dc.subject.otherTreatment failureen_US
dc.subject.otherPneumoniaen_US
dc.titleRisk factors of treatment failure in community acquired pneumonia: Implications for disease outcomeen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1136/thx.2003.017756en_US
dc.identifier.scopus2-s2.0-4644314994-
dc.contributor.authorscopusid7102205716-
dc.contributor.authorscopusid7401785975-
dc.contributor.authorscopusid7003514650-
dc.contributor.authorscopusid6602555827-
dc.contributor.authorscopusid6506770332-
dc.contributor.authorscopusid16168865800-
dc.contributor.authorscopusid6506821657-
dc.contributor.authorscopusid7003705264-
dc.contributor.authorscopusid55942667000-
dc.contributor.authorscopusid7004176630-
dc.contributor.authorscopusid7101996483-
dc.contributor.authorscopusid6603545516-
dc.contributor.authorscopusid7004670963-
dc.contributor.authorscopusid7101888516-
dc.contributor.authorscopusid7202925320-
dc.contributor.authorscopusid6603804487-
dc.description.lastpage965en_US
dc.description.firstpage960en_US
dc.relation.volume59en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.date.coverdateJulio 2004en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr5,04-
dc.description.jcrqQ1-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptPatología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Médicas y Quirúrgicas-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez De Castro, Felipe Carlos B.-
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