Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46593
Title: New antimicrobial molecules and new antibiotic strategies
Authors: De Castro, Felipe Rodríguez 
Naranjo, Olga Rajas
Marco, Javier Aspa
Violán, Jordi Solé
Keywords: Community-Acquired Pneumonia
Bacteremic Pneumococcal Pneumonia
Resistant Staphylococcus-Aureus
Respiratory-Tract Infections
Ventilator-Associated Pneumonia
Streptococcus-Pneumoniae
Double-Blind
Nosocomial Pneumonia
Beta-Lactam
Telithromycin
Issue Date: 2009
Publisher: 1069-3424
Journal: Seminars in Respiratory and Critical Care Medicine 
Abstract: Drug options for treatment of infections are increasingly limited. The pharmaceutical industry has found it difficult to discover new antimicrobial agents, and only two novel classes of antibiotics, the oxazolidinones and the cyclic lipopeptides, have entered the market since the late 1960s. Few new agents have reached the market in the last decade with potential interest for community-acquired pneumonia (CAP) treatment, including linezolid (the first oxazolidinone in clinical use), new fluoroquinolones, cefditoren, ertapenem, and telithromycin. Agents currently in clinical development include other novel quinolones and ketolides, broad-spectrum cephalosporin derivatives, faropenem, several glycopeptides, and iclaprim. Other molecules are considered to be promising candidates for the future. In addition to the foregoing agents, alternative treatment approaches have also been introduced into clinical practice, which include the administration of the appropriate antimicrobials in a timely manner and the consideration of the pharmacokinetic-pharmacodynamic properties of the agent(s).
URI: http://hdl.handle.net/10553/46593
ISSN: 1069-3424
DOI: 10.1055/s-0029-1202935
Source: Seminars in Respiratory and Critical Care Medicine[ISSN 1069-3424],v. 30, p. 161-171
Appears in Collections:Reseña
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