Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/46577
Title: Community acquired pneumonia: Genetic variants influencing systemic inflammation
Authors: Ferrer Agüero, J. M.
Millán, S.
Rodríguez de Castro, F. 
Martín-Loeches, I.
Solé Violán, J.
Keywords: Mannose-Binding Lectin
C-Reactive Protein
Septic Shock
Promoter Polymorphism
Respiratory-Failure
Susceptibility
Association
Infection
Mortality
Severity
Issue Date: 2014
Publisher: 0210-5691
Journal: Medicina Intensiva 
Abstract: The inflammatory response depends on several factors, including pathogenicity and duration of the stimulus, and also on the balance between inflammatory and antiinflammatory response. Several studies have presented evidence of the importance of genetic factors in severe infections. The innate immune response prevents the invasion and spread of pathogens during the first hours after infection. Each of the different processes involved in innate immunity may be affected by genetic polymorphisms, which can result in susceptibility or resistance to infection. The results obtained in the different studies do not irrefutably prove the role or function of a gene in the pathogenesis of respiratory infections. However, they can generate new hypotheses, suggest new candidate genes based on their role in the inflammatory response, and constitute a first step in understanding the underlying genetic factors. (C) 2013 Elsevier Espana, S.L. and SEMICYUC. All rights reserved.
URI: http://hdl.handle.net/10553/46577
ISSN: 0210-5691
DOI: 10.1016/j.medin.2013.08.002
Source: Medicina Intensiva[ISSN 0210-5691],v. 38, p. 315-323
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