Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45947
DC FieldValueLanguage
dc.contributor.authorLeón, Cristóbalen_US
dc.contributor.authorRuiz-Santana, Sergioen_US
dc.contributor.authorSaavedra, Pedroen_US
dc.contributor.authorCastro, Carmenen_US
dc.contributor.authorÚbeda, Alejandroen_US
dc.contributor.authorLoza, Anaen_US
dc.contributor.authorMartín-Mazuelos, Estrellaen_US
dc.contributor.authorBlanco, Armandoen_US
dc.contributor.authorJerez, Vicenteen_US
dc.contributor.authorBallús, Josepen_US
dc.contributor.authorÁlvarez-Rocha, Luisen_US
dc.contributor.authorUtande-Vázquez, Aránzazuen_US
dc.contributor.authorFariñas, Osvaldoen_US
dc.date.accessioned2018-11-23T00:06:10Z-
dc.date.available2018-11-23T00:06:10Z-
dc.date.issued2012en_US
dc.identifier.issn0342-4642en_US
dc.identifier.urihttp://hdl.handle.net/10553/45947-
dc.description.abstractTo assess the value of (1 -> 3)-beta-d-glucan (BDG), Candida albicans germ tube antibody (CAGTA), C-reactive protein (CRP), and procalcitonin (PCT) levels for the diagnosis of invasive candidiasis (IC) and for differentiating Candida spp. colonization from infection in ICU patients with severe abdominal conditions (SAC).Prospective study of 176 non-neutropenic patients, with SAC at ICU admission, and expected to stay at least 7 days. Surveillance cultures and BDG, CAGTA, CRP, and PCT levels were performed on the third day of ICU stay and twice a week for four consecutive weeks. Patients were grouped into invasive candidiasis (IC), Candida colonization, and neither colonized/nor infected. The classification and regression tree (CART) analysis was used to predict IC in colonized patients. The discriminatory ability of the obtained prediction rule was assessed by the area under the ROC curve (AUC).The probabilities of IC were 59.3 % for the terminal node of BDG greater than 259 pg/mL and 30.8 % for BDG less than 259 pg/mL and CAGTA positivity, whereas there was a 93.9 % probability in predicting the absence of IC for BDG less than 259 pg/mL and negative CAGTA. Using a cutoff of 30 % for IC probability, the prediction rule showed 90.3 % sensitivity, 54.8 % specificity, 42.4 % positive predictive value, and 93.9 % negative predictive value with an AUC of 0.78 (95 % confidence interval 0.76-0.81). Significant differences in CRP (p = 0.411) and PCT (p = 0.179) among the studied groups were not found.BDG with a positive test for CAGTA accurately differentiated Candida colonization from IC in patients with SAC, whereas CRP and PCT did not.en_US
dc.languageengen_US
dc.relation.ispartofIntensive Care Medicineen_US
dc.sourceIntensive Care Medicine [ISSN 0342-4642],v. 38, p. 1315-1325en_US
dc.subject32 Ciencias médicasen_US
dc.subject3201 Ciencias clínicasen_US
dc.subject.otherIntensive-Care-Uniten_US
dc.subject.otherCritically-Ill Patientsen_US
dc.subject.otherFungal-Infectionsen_US
dc.subject.otherDiagnosisen_US
dc.subject.otherAssayen_US
dc.subject.otherMulticenteren_US
dc.subject.otherScoreen_US
dc.subject.otherMetaanalysisen_US
dc.subject.otherSepsisen_US
dc.titleValue of β-D-glucan and Candida albicans germ tube antibody for discriminating between Candida colonization and invasive candidiasis in patients with severe abdominal conditionsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00134-012-2616-yen_US
dc.identifier.scopus84864281563-
dc.identifier.isi000306570100010-
dc.contributor.authorscopusid56666913400-
dc.contributor.authorscopusid55518542700-
dc.contributor.authorscopusid56677724200-
dc.contributor.authorscopusid17134137200-
dc.contributor.authorscopusid56522767100-
dc.contributor.authorscopusid6603120107-
dc.contributor.authorscopusid7003723314-
dc.contributor.authorscopusid16738146000-
dc.contributor.authorscopusid6603401925-
dc.contributor.authorscopusid6603461105-
dc.contributor.authorscopusid6506970343-
dc.contributor.authorscopusid37119425600-
dc.contributor.authorscopusid55260812200-
dc.description.lastpage1325en_US
dc.description.firstpage1315en_US
dc.relation.volume38en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid648096-
dc.contributor.daisngid839958-
dc.contributor.daisngid8838450-
dc.contributor.daisngid2803311-
dc.contributor.daisngid30339390-
dc.contributor.daisngid1551425-
dc.contributor.daisngid478423-
dc.contributor.daisngid609019-
dc.contributor.daisngid4016641-
dc.contributor.daisngid2335579-
dc.contributor.daisngid4428140-
dc.contributor.daisngid12979789-
dc.contributor.daisngid14407731-
dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Leon, C-
dc.contributor.wosstandardWOS:Ruiz-Santana, S-
dc.contributor.wosstandardWOS:Saavedra, P-
dc.contributor.wosstandardWOS:Castro, C-
dc.contributor.wosstandardWOS:Ubeda, A-
dc.contributor.wosstandardWOS:Loza, A-
dc.contributor.wosstandardWOS:Martin-Mazuelos, E-
dc.contributor.wosstandardWOS:Blanco, A-
dc.contributor.wosstandardWOS:Jerez, V-
dc.contributor.wosstandardWOS:Ballus, J-
dc.contributor.wosstandardWOS:Alvarez-Rocha, L-
dc.contributor.wosstandardWOS:Utande-Vazquez, A-
dc.contributor.wosstandardWOS:Farinas, O-
dc.date.coverdateAgosto 2012en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,944
dc.description.jcr5,258
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGrupo de investigaciones infecciosas, nutricionales e inflamatorias en pacientes hospitalarios / Study Group on infectious, nutritional and inflammatory diseases in hospitalized patients-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-3927-3236-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRuiz Santana, Sergio-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

77
checked on Sep 19, 2021

WEB OF SCIENCETM
Citations

74
checked on Sep 19, 2021

Page view(s)

14
checked on Jul 31, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.