Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45843
DC FieldValueLanguage
dc.contributor.authorMelián Limiñana, Carlosen_US
dc.contributor.authorPeterson, Mark E.en_US
dc.date.accessioned2018-11-22T13:01:58Z-
dc.date.available2018-11-22T13:01:58Z-
dc.date.issued1996en_US
dc.identifier.issn0022-4510en_US
dc.identifier.urihttp://hdl.handle.net/10553/45843-
dc.description.abstractHypoadrenocorticism was diagnosed in 42 dogs over a two‐and‐a‐half‐year period. The disease occurred more commonly in young to middle‐aged dogs, with a female:male ratio of 2:1. Most dogs had chronic intermittent signs (eg, poor appetite, lethargy and vomiting), but more than a third were in acute adrenal crisis at the time of diagnosis. Serum biochemical testing revealed azotaemia, hyperphosphataemia, hyper‐kalaemia and hyponatraemia in almost all the dogs. In all dogs, results of adrenocorticotrophic hormone (ACTH) stimulation testing revealed a low to low‐normal serum baseline Cortisol concentration that failed to increase after ACTH administration. In two dogs with persistently normal serum electrolytes concentration, one had a markedly high plasma ACTH concentration diagnostic for primary hypoadrenocorticism, whereas the other had a low concentration confirming secondary hypoadrenocorticism. Fludrocortisone acetate was initially used for mineralocorticoid replacement in 33 of the 37 treated dogs withprimary hypoadrenocorticism (final median dosage, 27‐0 μg/kg/day), but supplementation was changed to desoxycorticos‐terone pivalate (DOCP) in four dogs because of poor response or adverse effects. Seven dogs with primary hypoadrenocorticism were treated with DOCP (final median dosage, 2‐02 mg/kg/month). Prednisone, initially administered to 36 dogs, was discontinued in 11 dogs because of side effects. Of the dogs treated with fludrocortisone, the response was considered good to excellent in 26 dogs (78.8 per cent), fair in three, and poor in four. All dogs treated with DOCP responded well.en_US
dc.languageengen_US
dc.publisher0022-4510
dc.relation.ispartofJournal of Small Animal Practiceen_US
dc.sourceJournal of Small Animal Practice [ISSN 0022-4510], v. 37, p. 268-275en_US
dc.subject310907 Patologíaen_US
dc.subject240118 Mamíferosen_US
dc.subject.otherFamilial Hypoadrenocorticismen_US
dc.subject.otherAdrenal Cortex Hyperfunctionen_US
dc.subject.otherTrilostaneen_US
dc.subject.otherCanis familiarisen_US
dc.subject.otherAdrenal insufficiencyen_US
dc.subject.otherProspective studyen_US
dc.subject.otherTreatment outcomeen_US
dc.titleDiagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/j.1748-5827.1996.tb02377.xen_US
dc.identifier.scopus0030157525-
dc.contributor.authorscopusid55220360000-
dc.contributor.authorscopusid57203633420-
dc.description.lastpage275en_US
dc.description.firstpage268en_US
dc.relation.volume37en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Diabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-1496-5706-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMelián Limiñana, Carlos-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

75
checked on Dec 8, 2024

WEB OF SCIENCETM
Citations

62
checked on Dec 8, 2024

Page view(s)

83
checked on Jun 15, 2024

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.