Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45842
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dc.contributor.authorPeterson, Mark E.en_US
dc.contributor.authorMelián Limiñana, Carlosen_US
dc.contributor.authorNichols, Rhetten_US
dc.date.accessioned2018-11-22T13:01:32Z-
dc.date.available2018-11-22T13:01:32Z-
dc.date.issued1997en_US
dc.identifier.issn0003-1488en_US
dc.identifier.urihttp://hdl.handle.net/10553/45842-
dc.description.abstractObjective: To determine whether measurement of baseline serum concentrations of total thyroxine (T4), and triiodothyronine (T3), free T4, and thyrotropin (thyroid-stimulating hormone; TSH) would aid in the diagnosis of hypothyroidism in dogs. Design: Prospective case series. Animals: 54 dogs with hypothyroidism, 54 euthyroid dogs with nonthyroidal disease initially suspected to have hypothyroidism, and 150 clinically normal dogs. Procedure: In the 54 dogs with hypothyroidism, diagnosis was established on the basis of clinical signs, results of routine laboratory and TSH stimulation tests, exclusion of concurrent nonthyroidal disease, and a good clinical response to treatment with L-thyroxine. Blood samples were collected from all dogs and were tested for thyroid hormone and TSH concentrations. Reference ranges for hormone concentrations were established on the basis of results for the 150 clinically normal dogs. Results: Of the 54 hypothyroid dogs, 48 (89%) had low total T4 concentrations, 3 had low-normal concentrations, and 3 had high concentrations because of T4 autoantibodies. In contrast, only 10 (18%) euthyroid dogs had low total T4 concentrations. Only 3 of 31 (10%) hypothyroid dogs had low T3 concentrations; 23 had concentrations within the reference range, and 5 had high concentrations because of T3 autoantibodies. Only 3 of 38 euthyroid dogs had low T3 concentrations. Of the hypothyroid dogs, 53 (98%) had low free T4 concentrations and 1 had a low-normal concentration. Only 4 (7%) euthyroid dogs had low free T4 concentrations. Of the hypothyroid dogs, 41 (76%) had high TSH concentrations, and 13 had TSH concentrations within the reference range. Of the euthyroid dogs, only 4 (8%) had high TSH concentrations. Of all single hormone measurements evaluated, measurement of free T4 concentration had the highest sensitivity (0.98), specificity (0.93), and accuracy (0.95) as a test for hypothyroidism; measurement of total T4 concentration had a lower sensitivity (0.89), specificity (0.82), and accuracy (0.85). Compared with measurement of total or free T4 concentration, measurement of TSH concentration had a lower sensitivity (0.76) and accuracy (0.84) but specificity (0.93) equal to that for measurement of free T4 concentration. When T4 (total or free) and TSH concentrations were evaluated together, specificity was higher than when T4 or TSH concentration was evaluated alone. Only 1 euthyroid dog had low T4 (total and free) and high TSH concentrations. Clinical implications: Results indicate that measurement of serum free T4 and TSH concentrations is useful for diagnosis of hypothyroidism in dogs. About a quarter of the dogs with confirmed hypothyroidism, however, will have serum TSH concentrations within reference limits.en_US
dc.languageengen_US
dc.publisher0003-1488
dc.relation.ispartofJournal of the American Veterinary Medical Associationen_US
dc.sourceJournal of the American Veterinary Medical Association [ISSN 0003-1488], v. 211 (11), p. 1396-1402en_US
dc.subject310907 Patologíaen_US
dc.subject240118 Mamíferosen_US
dc.subject.otherHypothyroidismen_US
dc.subject.otherThyrotropinen_US
dc.subject.otherLevothyroxine Sodiumen_US
dc.subject.otherDogen_US
dc.subject.otherProspective studyen_US
dc.subject.otherRadioimmunoassayen_US
dc.subject.otherThyroxineen_US
dc.subject.otherTriiodothyronineen_US
dc.titleMeasurement of serum total thyroxine, triiodothyronine, free thyroxine, and thyrotropin concentrations for diagnosis of hypothyroidism in dogsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.scopus0031450374-
dc.contributor.authorscopusid57203633420-
dc.contributor.authorscopusid55220360000-
dc.contributor.authorscopusid7201505195-
dc.description.lastpage1402en_US
dc.description.firstpage1396en_US
dc.relation.volume211 (11)en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.jcr0,948
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDiabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-1496-5706-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMelián Limiñana, Carlos-
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