Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45839
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dc.contributor.authorKantrowitz, Lawrence B.en_US
dc.contributor.authorPeterson, Mark E.en_US
dc.contributor.authorTrepanier, Lauren A.en_US
dc.contributor.authorMelián Limiñana, Carlosen_US
dc.contributor.authorNichols, Rhetten_US
dc.date.accessioned2018-11-22T13:00:11Z-
dc.date.available2018-11-22T13:00:11Z-
dc.date.issued1999en_US
dc.identifier.issn0003-1488en_US
dc.identifier.urihttp://hdl.handle.net/10553/45839-
dc.description.abstractObjective: To determine whether administration of phenobarbital, potassium bromide, or both drugs concurrently was associated with abnormalities in baseline serum total thyroxine (T4), triiodothyronine (T3), free T4, or thyrotropin (thyroid-stimulating hormone; TSH) concentrations in epileptic dogs. Design: Prospective case series. Animals: 78 dogs with seizure disorders that did not have any evidence of a thyroid disorder (55 treated with phenobarbital alone, 15 treated with phenobarbital and bromide, and 8 treated with bromide alone) and 150 clinically normal dogs that were not receiving any medication. Procedure: Serum total T4, total T3, free T4, and TSH concentrations, as well as serum concentrations of anticonvulsant drugs, were measured in the 78 dogs with seizure disorders. Reference ranges for hormone concentrations were established on the basis of results from the 150 clinically normal dogs. Results: Total and free T4 concentrations were significantly lower in dogs receiving phenobarbital (alone or with bromide), compared with concentrations in clinically normal dogs. Administration of bromide alone was not associated with low total or free T4 concentration. Total T3 and TSH concentrations did not differ among groups of dogs. Clinical implications: Results indicate that serum total and free T4 concentrations may be low (i.e., in the range typical for dogs with hypothyroidism) in dogs treated with phenobarbital. Serum total T3 and TSH concentrations were not changed significantly in association with phenobarbital administration. Bromide treatment was not associated with any significant change in these serum thyroid hormone concentrations.en_US
dc.languageengen_US
dc.publisher0003-1488
dc.relation.ispartofJournal of the American Veterinary Medical Associationen_US
dc.sourceJournal of the American Veterinary Medical Association [ISSN 0003-1488], v. 214 (12), p. 1804-1808en_US
dc.subject310908 Farmacologíaen_US
dc.subject240118 Mamíferosen_US
dc.subject.otherHypothyroidismen_US
dc.subject.otherThyrotropinen_US
dc.subject.otherLevothyroxine Sodiumen_US
dc.subject.otherAnimal experimenten_US
dc.subject.otherAnticonvulsant therapyen_US
dc.subject.otherDrug effecten_US
dc.subject.otherDrug safetyen_US
dc.subject.otherEpilepsyen_US
dc.subject.otherLiothyronine blood levelen_US
dc.subject.otherThyroxine blood levelen_US
dc.subject.otherCanis familiarisen_US
dc.titleSerum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in epileptic dogs treated with anticonvulsantsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.scopus0033564860-
dc.contributor.authorscopusid6603209520-
dc.contributor.authorscopusid57203633420-
dc.contributor.authorscopusid7006537265-
dc.contributor.authorscopusid55220360000-
dc.contributor.authorscopusid7201505195-
dc.description.lastpage1808en_US
dc.description.firstpage1804en_US
dc.relation.volume214 (12)en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-VETen_US
dc.description.jcr1,165
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDiabetes y endocrinología aplicada-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-1496-5706-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMelián Limiñana, Carlos-
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