Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45706
Título: The Pathology of Wobbly Hedgehog Syndrome
Autores/as: Diaz Delgado, Josue 
Whitley, Derick B.
Storts, Ralph W.
Heatley, J. Jill
Hoppes, Sharman M.
Porter, Brian F.
Clasificación UNESCO: 310907 Patología
Palabras clave: Atelerix albiventris
Erinaceus europaeus
Hedgehog
Myelin
Myelinopathy, et al.
Fecha de publicación: 2018
Editor/a: 0300-9858
Publicación seriada: Veterinary Pathology 
Resumen: Wobbly hedgehog syndrome (WHS) is a leading cause of neurologic disease in African pygmy hedgehogs (APHs;Atelerix albi-ventris). This study describes the signalment, clinical signs, gross, microscopic, and ultrastructural lesions of WHS in a cohort of 12pet APHs. Microscopically, lesions consisted of status spongiosus of the white matter, typically bilateral and symmetrical, withmyelin degeneration and loss that was accompanied by neuronal/axonal degeneration plus reactive microgliosis and mild, focalastrocytosis and astrogliosis. Lesions were most severe in the cerebellum and medulla oblongata, as well as cervical and thoracicspinal cord. Less affected areas were the corona radiata, corpus callosum, corpus striatum, internal capsule, and the mesence-phalon. Ultrastructurally, the lesions consisted of splitting of the myelin sheath at the intraperiod line with subsequent focalexpansion, resulting in status spongiosus, disruption, dilatation, rhexis, and phagocytosis. Based on these results, WHS is bestdescribed as a “spongy myelinopathy” with widespread central nervous system involvement.
URI: http://hdl.handle.net/10553/45706
ISSN: 0300-9858
DOI: 10.1177/0300985818768033
Fuente: Veterinary Pathology [ISSN 0300-9858], v. 55, p. 711-718
Colección:Artículos
Vista completa

Citas SCOPUSTM   

16
actualizado el 24-mar-2024

Visitas

61
actualizado el 02-mar-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.