Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45523
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dc.contributor.authorMonzón-Mayor, M.
dc.contributor.authorYanes, C.
dc.contributor.authorRenau-Piqueras, J.
dc.date.accessioned2018-11-22T10:30:44Z-
dc.date.available2018-11-22T10:30:44Z-
dc.date.issued1998
dc.identifier.issn1121-760X
dc.identifier.urihttp://hdl.handle.net/10553/45523-
dc.description.abstractThe location and chronology during development of the immunoreactivity due to the presence of neurofilaments (NF) in telencephalon and mesencephalon of the lizard Gallotia galloti has been studied. For this purpose we have used two antibodies recognizing both phosphorylated and non phosphorylated neurofilaments (NF), a polyclonal Ab (NF 005), and a commercial monoclonal antibody (NF-200). The study was completed by using the Bielschowsky technique.During ontogeny, the anti-NF 005 immunoreactivity appeared at E40 in some tracts in mesencephalon and increased in intensity in isolated nerve fibers, tracts and commissurae till adult. However, a weak staining appeared in some neurons. In telencephalon, the reactivity was detected only in adult specimens. It was clearly more abundant in mesencephnlon than in telencephalon, which could indicate that a greater complexity and functional importance exist in the lizard midbrain in relation to other primitive regions as the basal nuclei and cortical areas. In contrast to young specimens, the monoclonal anti-NF 200 was detected in neuronal perikarya, dendrites and axons in adults.Thus, in lizards, both antibodies highly recognized phosphorylated and non-phosphorylated forms of proteins of NF (NF-H). In mammals, these forms of proteins are implicated in axonal maturation. The presence of these NF in reptiles, identified for the first time, proved to be phylogenetically stable. The anti-NF immunoreactivity distribution occurs both caudo-rostrally and from the ventral to the dorsal regions.
dc.publisher1121-760X
dc.relation.ispartofEuropean Journal of Histochemistry
dc.sourceEuropean Journal of Histochemistry[ISSN 1121-760X],v. 42, p. 213-226
dc.subject.otherDorsal Ventricular Ridge
dc.subject.otherCentral-Nervous-System
dc.subject.otherSpinal-Cord
dc.subject.otherMonoclonal-Antibodies
dc.subject.otherImmunohistochemical Localization
dc.subject.otherPosttranslational Modification
dc.subject.otherVaranus-Exanthematicus
dc.subject.otherAxoplasmic-Transport
dc.subject.otherAxonal Maturation
dc.subject.otherNeurite Growth
dc.titleDistribution of neurofilaments in the telencephalon and mesencephalon of the adult and developing Gallotia galloti lizard
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.scopus0031736046
dc.identifier.isi000076038600006
dc.contributor.authorscopusid36793900900
dc.contributor.authorscopusid7004187530
dc.contributor.authorscopusid7006666243
dc.description.lastpage226
dc.description.firstpage213
dc.relation.volume42
dc.type2Artículoes
dc.contributor.daisngid901526
dc.contributor.daisngid675718
dc.contributor.daisngid451790
dc.contributor.wosstandardWOS:Monzon-Mayor, M
dc.contributor.wosstandardWOS:Yanes, C
dc.contributor.wosstandardWOS:Renau-Piqueras, J
dc.date.coverdateDiciembre 1998
dc.identifier.ulpgces
dc.description.jcr0,453
dc.description.jcrqQ4
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptTecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptMorfología-
crisitem.author.orcid0000-0002-5046-508X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMonzón Mayor, Maximina-
crisitem.author.fullNameYanes Mendez, Carmen M-
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