Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45519
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dc.contributor.authorRomero-Alemán, María del Mar
dc.contributor.authorMonzón-Mayor, Maximina
dc.contributor.authorYanes, Carmen
dc.contributor.authorArbelo-Galván, Juan Francisco
dc.contributor.authorLang, Dirk
dc.contributor.authorRenau-Piqueras, Jaime
dc.contributor.authorNegrín-Martínez, Ciro
dc.contributor.otherLang, Dirk
dc.contributor.otherROMERO-ALEMAN, MARIA DEL MAR
dc.contributor.otherMonzon-Mayor, Maximina
dc.date.accessioned2018-11-22T10:28:52Z-
dc.date.available2018-11-22T10:28:52Z-
dc.date.issued2003
dc.identifier.issn0022-3034
dc.identifier.urihttp://hdl.handle.net/10553/45519-
dc.description.abstractWe identified S100 immunoreactive cells in the brain of the lizard Gallotia galloti during ontogeny using immunohistochemical techniques for light and electron microscopy. In double labeling experiments with antibodies specific for S100A1 and S100B (anti-S100) and proliferative cell nuclear antigen (anti-PCNA), myelin basic protein (anti-MBP), phosphorylated neurofilaments (SMI-31), glial fibrillary acidic protein (anti-GFAP), or glutamine synthetase (anti-GS), we detected S100-like immunoreactivity in glial cells but never in neurons. Restricted areas of the ventricular zone were stained in the hypothalamus from E32 to postnatal stages, and in the telencephalon at E35, E36, and in adults. S100 immunoreactivity was observed predominantly in scattered PCNA-negative cells that increased in number from E35 to the adult stage in the myelinated tracts of the brain and had the appearance of oligodendrocytes. Quantitative analysis revealed that all of the S100-positive glial cells were GFAP-negative, whereas most of the S100-positive glial cells were GS-positive. Ultrastructurally, most of these S100-positive/GS-positive glial cells resembled oligodendrocytes of light and medium electron density. In adult lizards, a small subpopulation of astrocyte-like cells was also stained in the pretectum. We conclude that in the lizard S100 can be considered a marker of a subpopulation of oligodendrocytes rather than of astrocytes, as is the case in mammals. The S100-positive subpopulation of oligodendrocytes in the lizard could represent cells actively involved in the process of myelination during development and in the maintenance of myelin sheaths in the adult. (C) 2003 Wiley Periodicals, Inc.
dc.publisher0022-3034
dc.relation.ispartofJournal of Neurobiology
dc.sourceJournal of Neurobiology[ISSN 0022-3034],v. 57, p. 54-66
dc.subject.otherMyelin Basic-Protein
dc.subject.otherRat Optic-Nerve
dc.subject.otherImmunohistochemical Localization
dc.subject.otherVisual-Cortex
dc.subject.otherS-100 Protein
dc.subject.otherAdult-Rat
dc.subject.otherOligodendrocytes
dc.subject.otherBrain
dc.subject.otherGliogenesis
dc.subject.otherExpression
dc.titleS100 immunoreactive glial cells in the forebrain and midbrain of the lizard Gallotia galloti during ontogeny
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1002/neu.10258
dc.identifier.scopus0042385112-
dc.identifier.isi000185210700005
dcterms.isPartOfJournal Of Neurobiology
dcterms.sourceJournal Of Neurobiology[ISSN 0022-3034],v. 57 (1), p. 54-66
dc.contributor.authorscopusid6506533545
dc.contributor.authorscopusid36793900900
dc.contributor.authorscopusid7004187530
dc.contributor.authorscopusid6506602441
dc.contributor.authorscopusid7202375282
dc.contributor.authorscopusid7006666243
dc.contributor.authorscopusid6505525090
dc.description.lastpage66
dc.description.firstpage54
dc.relation.volume57
dc.type2Artículoes
dc.identifier.wosWOS:000185210700005
dc.contributor.daisngid1157526
dc.contributor.daisngid901526
dc.contributor.daisngid675718
dc.contributor.daisngid5740302
dc.contributor.daisngid626938
dc.contributor.daisngid451790
dc.contributor.daisngid11865715
dc.identifier.investigatorRIDI-2554-2015
dc.identifier.investigatorRIDK-8038-2014
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Romero-Aleman, MD
dc.contributor.wosstandardWOS:Monzon-Mayor, M
dc.contributor.wosstandardWOS:Yanes, C
dc.contributor.wosstandardWOS:Arbelo-Galvan, JF
dc.contributor.wosstandardWOS:Lang, D
dc.contributor.wosstandardWOS:Renau-Piqueras, J
dc.contributor.wosstandardWOS:Negrin-Martinez, C
dc.date.coverdateOctubre 2003
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptTecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7987-5509-
crisitem.author.orcid0000-0002-5046-508X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRomero Alemán, María Del Mar-
crisitem.author.fullNameMonzón Mayor, Maximina-
crisitem.author.fullNameYanes Mendez, Carmen M-
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