Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45518
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dc.contributor.authorRomero-Aleman, MM
dc.contributor.authorMonzón-Mayor, M.
dc.contributor.authorYanes, C.
dc.contributor.authorLang, D.
dc.contributor.otherROMERO-ALEMAN, MARIA DEL MAR
dc.contributor.otherLang, Dirk
dc.contributor.otherMonzon-Mayor, Maximina
dc.date.accessioned2018-11-22T10:28:24Z-
dc.date.available2018-11-22T10:28:24Z-
dc.date.issued2004
dc.identifier.issn0014-4886
dc.identifier.urihttp://hdl.handle.net/10553/45518-
dc.description.abstractReptiles are the only amniotic vertebrates known to be capable of spontaneous regeneration of the central nervous system (CNS). In this study, we analyzed the reactive changes of glial cells in response to a unilateral physical lesion in the cerebral cortex of the lizard Gallotia galloti, at 1, 3, 15, 30, 120, and 240 days postlesion. The glial cell markers glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), S 100 protein, and tomato lectin, as well as proliferating cell nuclear antigen (PCNA) were used to evaluate glial changes occurring because of cortical lesions. A transitory and unilateral upregulation of GFAP and GS in reactive radial glial cells were observed from 15 to 120 days postlesion. In addition, reactive lectin-positive macrophage/microglia were observed from 1 to 120 days postlesion, whereas the expression of S100 protein remained unchanged throughout the examined postlesion period. The matricial zones closest to the lesion site, the sulcus lateralis (SL) and the sulcus septomedialis (SSM), showed significantly increased numbers of dividing cells at 30 days postlesion. At 240 days postlesion, the staining pattern for PCNA, GEAP, GS, and tomato lectin in the lesion site became similar to that observed in unlesioned controls. In addition, ultrastructural data of the lesioned cortex at 240 days postlesion indicated a structural repair process. We conclude that restoration of the glial framework and generation of new neurons and glial cells in the ventricular wall play a key role in the successful structural repair of the cerebral cortex of the adult lizard. (C) 2004 Elsevier Inc. All rights reserved.
dc.publisher0014-4886
dc.relation.ispartofExperimental neurology
dc.sourceExperimental Neurology[ISSN 0014-4886],v. 188 (1), p. 74-85
dc.subject.otherFibrillary Acidic Protein
dc.subject.otherEarly Postnatal Mouse
dc.subject.otherSpinal-Cord-Injury
dc.subject.otherOptic-Nerve Fibers
dc.subject.otherGlutamine-Synthetase
dc.subject.otherCns Myelin
dc.subject.otherSomatosensory Cortex
dc.subject.otherAxonal Regeneration
dc.subject.otherGrowth-Inhibitors
dc.subject.otherNeurite Growth
dc.titleRadial glial cells, proliferating periventricular cells, and microglia might contribute to successful structural repair in the cerebral cortex of the lizard Gallotia galloti
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.expneurol.2004.03.014
dc.identifier.scopus2942578314-
dc.identifier.isi000222174700008
dcterms.isPartOfExperimental Neurology
dcterms.sourceExperimental Neurology[ISSN 0014-4886],v. 188 (1), p. 74-85
dc.contributor.authorscopusid6506533545
dc.contributor.authorscopusid36793900900
dc.contributor.authorscopusid7004187530
dc.contributor.authorscopusid7202375282
dc.description.lastpage85
dc.description.firstpage74
dc.relation.volume188
dc.type2Artículoes
dc.identifier.wosWOS:000222174700008
dc.contributor.daisngid1157526
dc.contributor.daisngid901526
dc.contributor.daisngid675718
dc.contributor.daisngid626938
dc.identifier.investigatorRIDK-8038-2014
dc.identifier.investigatorRIDI-2554-2015
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Romero-Aleman, MM
dc.contributor.wosstandardWOS:Monzon-Mayor, M
dc.contributor.wosstandardWOS:Yanes, C
dc.contributor.wosstandardWOS:Lang, D
dc.date.coverdateJulio 2004
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptTecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7987-5509-
crisitem.author.orcid0000-0002-5046-508X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRomero Alemán, María Del Mar-
crisitem.author.fullNameMonzón Mayor, Maximina-
crisitem.author.fullNameYanes Mendez, Carmen M-
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