Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45517
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dc.contributor.authorSantos, Elena
dc.contributor.authorYanes, Carmen M.
dc.contributor.authorMonzón-Mayor, Maximina
dc.contributor.authorRomero-Alemán, Maria Del Mar
dc.contributor.otherROMERO-ALEMAN, MARIA DEL MAR
dc.contributor.otherMonzon-Mayor, Maximina
dc.date.accessioned2018-11-22T10:27:57Z-
dc.date.available2018-11-22T10:27:57Z-
dc.date.issued2006
dc.identifier.issn0022-3034
dc.identifier.urihttp://hdl.handle.net/10553/45517-
dc.description.abstractWe studied the myelination of the visual pathway during the ontogeny of the lizard Gallotia galloti using immunohistochemical methods to stain the myelin basic protein (MBP) and proteolipid protein (PLP/DM20), and electron microscopy. The staining pattern for the PLP/DM20 and MBP overlapped during the lizard ontogeny and was first observed at E39 in cell bodies and fibers located in the temporal optic nerve, optic chiasm, middle optic tract, and in the stratum album centrale of the optic tectum (OT). The expression of these proteins extended to the nerve fiber layer (NFL) of the temporal retina and to the outer strata of the OT at E40. From hatching onwards, the labeling became stronger and extended to the entire visual pathway. Our ultrastructural data in postnatal and adult animals revealed the presence of both myelinated and unmyelinated retinal ganglion cell axons in all visual areas, with a tendency for the larger axons to show the thicker myelin sheaths. Moreover, two kinds of oligodendrocytes were described: peculiar oligodendrocytes displaying loose myelin sheaths were only observed in the NFL, whereas typical medium electron-dense oligodendrocytes displaying compact myelin sheaths were observed in the rest of the visual areas. The weakest expression of the PLP/DM20 in the NFL of the retina appears to be linked to the loose appearance of its myelin sheaths. We conclude that typical and peculiar oligodendrocytes are involved in an uneven myelination process, which follows a temporo-nasal and rostro-caudal gradient in the retina and ON, and a ventro-dorsal gradient in the OT. (c) 2006 Wiley Periodicals, Inc.
dc.publisher0022-3034
dc.relation.ispartofJournal of Neurobiology
dc.sourceJournal of Neurobiology[ISSN 0022-3034],v. 66, p. 1115-1124
dc.subject.otherCentral-Nervous-System
dc.subject.otherOptic-Nerve
dc.subject.otherGallotia-Galloti
dc.subject.otherGlial-Cells
dc.subject.otherImmunohistochemical Localization
dc.subject.otherBasic-Protein
dc.subject.otherFiber Layer
dc.subject.otherRetina
dc.subject.otherRegeneration
dc.subject.otherChicken
dc.titlePeculiar and typical oligodendrocytes are involved in an uneven myelination pattern during the ontogeny of the lizard visual pathway
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1002/neu.20256
dc.identifier.scopus33747596230-
dc.identifier.isi000239905800007
dcterms.isPartOfJournal Of Neurobiology
dcterms.sourceJournal Of Neurobiology[ISSN 0022-3034],v. 66 (10), p. 1115-1124
dc.contributor.authorscopusid35084324600
dc.contributor.authorscopusid7004187530
dc.contributor.authorscopusid36793900900
dc.contributor.authorscopusid6506533545
dc.description.lastpage1124
dc.description.firstpage1115
dc.relation.volume66
dc.type2Artículoes
dc.identifier.wosWOS:000239905800007
dc.contributor.daisngid2816094
dc.contributor.daisngid675718
dc.contributor.daisngid901526
dc.contributor.daisngid1157526
dc.identifier.investigatorRIDK-8038-2014
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Santos, E
dc.contributor.wosstandardWOS:Yanes, CM
dc.contributor.wosstandardWOS:Monzon-Mayor, M
dc.contributor.wosstandardWOS:Romero-Aleman, MD
dc.date.coverdateSeptiembre 2006
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptTecnología Médica y Audiovisual-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptFarmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-5046-508X-
crisitem.author.orcid0000-0002-7987-5509-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameYanes Mendez, Carmen M-
crisitem.author.fullNameMonzón Mayor, Maximina-
crisitem.author.fullNameRomero Alemán, María Del Mar-
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