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Title: Dirofilaria immitis infection in dogs: Cardiopulmonary biomarker levels
Authors: Carretón Gomez, Elena 
Corbera Sánchez, Juan Alberto 
Juste de Santa Ana, Candelaria 
Morchon Garcia,Rodrigo 
Simón Martín,Fernando 
Montoya Alonso, José Alberto 
UNESCO Clasification: 240112 Parasitología animal
310907 Patología
Keywords: Dirofilaria immitis
Cardiac troponin I
Cardiac troponin T
D-Dimer, et al
Issue Date: 2011
Journal: Veterinary Parasitology 
Conference: 13th Triennial State of the Heartworm Symposium 2010 
Abstract: Cardiopulmonary biomarkers are biological parameters that can be objectively measured and quantified as indicators of pathogenic processes (heartworm disease) or as indicators of response to therapeutic intervention. To determine levels of cardiopulmonary biomarkers in canine dirofilariasis, measurements of cardiac troponin T, cardiac troponin I, myoglobin, and D-dimer concentrations were performed for dogs with and without evidence of adult heartworm infection. The results showed that levels of cardiac troponin T were undetectable in all dogs studied while levels of cardiac troponin I were higher in dogs infected with Dirofilaria immitis. In healthy dogs, levels of myoglobin and D-dimer were below detection limits of the instrument and were significantly higher in heartworm-infected dogs, notably in microfilaremic dogs. The results suggest the possibility of using troponin I and myoglobin as markers for cardiac damage and the D-dimer as a supportive tool for a diagnosis of pulmonary thromboembolism in dogs with cardiopulmonary dirofilariasis.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2011.01.015
Source: Veterinary Parasitology [ISSN 0304-4017], v. 176, p. 313-316, (Marzo 2011)
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