Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45314
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dc.contributor.authorFanjul, L. F.en_US
dc.contributor.authorEstevez, F.en_US
dc.contributor.authorDeniz, A.en_US
dc.contributor.authorMarrero, I.en_US
dc.contributor.authorBenitez, L.en_US
dc.contributor.authorQuintana, Jen_US
dc.contributor.authorGonzalez, J.en_US
dc.contributor.authorCentol, I.en_US
dc.contributor.authorRuiz de Galarreta, C. M.en_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherMarrero-Arencibia, Isabel-
dc.contributor.otherEstevez, Francisco-
dc.date.accessioned2018-11-22T08:52:32Z-
dc.date.available2018-11-22T08:52:32Z-
dc.date.issued1989en_US
dc.identifier.issn0158-5231en_US
dc.identifier.urihttp://hdl.handle.net/10553/45314-
dc.description.abstractThe influence of a synthetic androgen R1881 upon hCG stimulated steroidogenesis in cultured rat testicular cells was investigated. Testicular cells were cultured for 8 days in medium alone and thereafter reincubated for 48 h with appropriate treatments before the collection of media for steroid RIA. Addition of R1881 (10(-6) M) resulted in an overall decrease of hCG (0.3-10 ng/ml) stimulated pregnenolone and progesterone production by cultured cells. The conversion of exogenous steroids of the delta 4 pathway (progesterone,17 alpha-OH-P and delta 4-A) was also studied in cultures supplemented with cyanoketone (10(-5) M) and/or spironolactone (10(-5) M) to prevent endogenous testosterone production. R1881 inhibited progesterone and 17 alpha-OH-P conversion to testosterone (T) and was ineffective when delta 4-A served as precursor for T biosynthesis. The inhibitory effect of R1881 upon Testosterone production was prevented by concomitant treatment with CPA. These observations suggest that R1881 decreases the hCG stimulated testosterone production via inhibition of CSCCE,3 beta-HSD,C17-20 Lyase and likely 17 alpha-Hydroxylase, whereas no effect on 17 beta-HSD could be observed.en_US
dc.languageengen_US
dc.relation.ispartofBiochemistry Internationalen_US
dc.sourceBiochemistry International [ISSN 0158-5231], v. 19, p. 301-312en_US
dc.subject32 Ciencias médicasen_US
dc.subject2403 Bioquímicaen_US
dc.subject.otherR1881en_US
dc.subject.otherSteroidogenesisen_US
dc.subject.otherTesticular cellsen_US
dc.titleR1881 regulation of steroidogenesis in cultured testicular cellsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.scopus0024449843-
dc.identifier.isiA1989AN27700010-
dcterms.isPartOfBiochemistry International-
dcterms.sourceBiochemistry International[ISSN 0158-5231],v. 19 (2), p. 301-312-
dc.contributor.authorscopusid7004158812-
dc.contributor.authorscopusid7003810011-
dc.contributor.authorscopusid7004186223-
dc.contributor.authorscopusid35936487800-
dc.contributor.authorscopusid7004409333-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid57198495832-
dc.contributor.authorscopusid6505759813-
dc.contributor.authorscopusid7003806034-
dc.description.lastpage312en_US
dc.description.firstpage301en_US
dc.relation.volume19en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:A1989AN27700010-
dc.contributor.daisngid1127140-
dc.contributor.daisngid384944-
dc.contributor.daisngid265045-
dc.contributor.daisngid3844163-
dc.contributor.daisngid555851-
dc.contributor.daisngid128315-
dc.contributor.daisngid19597998-
dc.contributor.daisngid8461416-
dc.contributor.daisngid1664323-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDQ-9437-2016-
dc.identifier.investigatorRIDK-5125-2014-
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.date.coverdateAgosto 1989en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0009-0000-1982-055X-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFanjul Rodríguez, Luisa Fernanda-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
crisitem.author.fullNameQuintana Aguiar, José Martín-
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