Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45310
Título: Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes
Autores/as: Sanchez-Bueno, A.
Marrero, I. 
Cobbold, P. H.
Clasificación UNESCO: 32 Ciencias médicas
320502 Endocrinología
Palabras clave: Cytosolic Ca2+
Phenylephrine
Vasopressin
Rat hepatocytes
Fecha de publicación: 1993
Publicación seriada: Biochemical Journal 
Resumen: We show here, by aequorin measurements in single isolated rat hepatocytes, that elevation of cyclic AMP, by dibutyryl cyclic AMP, forskolin or glucagon, has different effects on oscillations in cytosolic concentration of free Ca2+ ('free Ca') induced by phenylephrine or vasopressin. Elevated cyclic AMP does not itself induce free Ca oscillations, but enhances both the peak free Ca and the frequency of spikes induced by phenylephrine. In contrast, elevated cyclic AMP has no effect on peak free Ca of vasopressin-induced spikes, but markedly prolongs the falling phase, with the result that spiking frequency (peak to peak) falls, although the period between spikes of resting free Ca is usually decreased. The data provide another example of receptor-specific information being retained in the oscillator mechanism, with implications for models of the hepatocyte calcium oscillator.
URI: http://hdl.handle.net/10553/45310
ISSN: 0264-6021
DOI: 10.1042/bj2910163
Fuente: Biochemical Journal [ISSN 0264-6021], v. 291, p. 163-168
Colección:Artículos
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