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Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/45305
DC FieldValueLanguage
dc.contributor.authorMarrero Arencibia, María Isabelen_US
dc.contributor.authorGreen, A. K.en_US
dc.contributor.authorDixon, C. J.en_US
dc.contributor.authorPh Cobbolden_US
dc.date.accessioned2018-11-22T08:48:20Z-
dc.date.available2018-11-22T08:48:20Z-
dc.date.issued1997en_US
dc.identifier.issn1074-939Xen_US
dc.identifier.urihttp://hdl.handle.net/10553/45305-
dc.description.abstractBovine growth hormone (bGH) induces calcium transients in rat hepatocytes. To investigate the role of phospholipase C (PLC) in these hormone-stimulated calcium signals, the effects of U-73122 (1-[6-[[17β-3-methoxyestra-1,3,5(10)-trien-17-yl] amino] hexyl]-1 H-pyrrole-2,5-dione), an inhibitor of phospholipase C, and its inactive analog, U-73343 (1-[6-[17β-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1 H-pyrrolidine-2,5-dione), were determined. Intracellular calcium transients were measured in single rat hepatocytes microinjected with the photoprotein aequorin. Exposure to U-73122 inhibited bGH stimulated calcium transients. U-73343 elicited no effects. Also we show here that an inhibitor of dyacylglycerol kinase (R 59 022) inhibits free Ca oscillations induced by growth hormone. In conclusion, these results support the hypothesis that PLC plays a role in the calcium transients elicited by bGH and a negative feedback effect of protein kinase C on free Ca oscillations GH-induced.en_US
dc.languageengen_US
dc.relation.ispartofEndocrinology and Metabolism, Supplementen_US
dc.sourceEndocrinology and Metabolism, Supplement [ISSN 1074-939X], v. 4, p. 77en_US
dc.subject32 Ciencias médicasen_US
dc.subject320502 Endocrinologíaen_US
dc.subject.otherPhospholipase Cen_US
dc.subject.otherHormoneen_US
dc.subject.otherRat hepatocytesen_US
dc.titleP-109. U-73122, a phospholipase c antagonist inhibits effects of growth hormone on calcium in rat hepatocytesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.scopus33747668793-
dc.contributor.authorscopusid35936487800-
dc.contributor.authorscopusid35581812600-
dc.contributor.authorscopusid7101861128-
dc.contributor.authorscopusid14122012600-
dc.description.lastpage77en_US
dc.description.firstpage77en_US
dc.relation.volume4en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.description.numberofpages1en_US
dc.utils.revisionSíen_US
dc.date.coverdateEnero 1997en_US
dc.identifier.ulpgcSíen_US
dc.contributor.buulpgcBU-MEDen_US
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
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