Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/45304
Campo DC Valoridioma
dc.contributor.authorMarrero Arencibia, María Isabelen_US
dc.contributor.authorDéniz, A.en_US
dc.contributor.otherMarrero-Arencibia, Isabel-
dc.date.accessioned2018-11-22T08:47:53Z-
dc.date.available2018-11-22T08:47:53Z-
dc.date.issued2004en_US
dc.identifier.issn1096-6374en_US
dc.identifier.urihttp://hdl.handle.net/10553/45304-
dc.description.abstractWe investigated the effects of bovine GH (bGH) on Ca2+ handling, phospholipase C (PLC) activation and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] formation in hepatocytes. bGH generates oscillations in cytosolic free Ca2+ concentration ([Ca2+]i) in single male rat hepatocytes microinjected with the photoprotein aequorin. In the absence of extracellular Ca2+ these transients persisted for more than 10 min indicating a requirement for intracellular Ca2+. Treatment of the hepatocyte with the phosphatidylinositol-specific phospholipase C (PI-PLC) inhibitor U-73122 removed the oscillations. These results suggest bGH-induced oscillations are due to PLC activation and generation of Ins(1,4,5)P3. We measured the mass of Ins(1,4,5)P3 in freshly isolated hepatocyte suspensions in response to bGH, and vasopressin as a control. Both agonists rapidly increased the levels of Ins(1,4,5)P3. This is the first study to indicate that early events in the signal transduction pathways mediated by GH in hepatocytes involve intracellular Ca2+ mobilization via activation of a PI-PLC and subsequent Ins(1,4,5 )P3 production.en_US
dc.languageengen_US
dc.relation.ispartofGrowth Hormone and IGF Researchen_US
dc.sourceGrowth Hormone & Igf Research [ISSN 1096-6374],v. 14 (2), p. 85-90en_US
dc.subject32 Ciencias médicasen_US
dc.subject320102 Genética clínicaen_US
dc.subject2415 Biología molecularen_US
dc.subject.otherIsolated Rat Hepatocytesen_US
dc.subject.otherC-Dependent Processesen_US
dc.subject.otherPolymorphonuclear Neutrophilsen_US
dc.subject.otherInositol 1,4,5-Trisphosphateen_US
dc.subject.otherSignal-Transductionen_US
dc.subject.otherSingle Hepatocytesen_US
dc.subject.otherCa2+ Oscillationsen_US
dc.subject.otherReceptor-Familyen_US
dc.subject.otherIncreasesen_US
dc.subject.otherStimulationen_US
dc.titleThe phospholipase C-InsP(3) pathway is involved in calcium mobilization induced by growth hormone in hepatocytesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ghir.2003.11.001en_US
dc.identifier.scopus4644285625-
dc.identifier.isi000220348900002-
dcterms.isPartOfGrowth Hormone & Igf Research-
dcterms.sourceGrowth Hormone & Igf Research[ISSN 1096-6374],v. 14 (2), p. 85-90-
dc.contributor.authorscopusid35936487800-
dc.contributor.authorscopusid7004186223-
dc.description.lastpage90en_US
dc.identifier.issue2-
dc.description.firstpage85en_US
dc.relation.volume14en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000220348900002-
local.message.claim2022-07-07T13:37:01.370+0100|||rp01911|||submit_approve|||dc_contributor_author|||None*
dc.contributor.daisngid1533885-
dc.contributor.daisngid3844163-
dc.contributor.daisngid265045-
dc.contributor.daisngid1859307-
dc.identifier.investigatorRIDQ-9437-2016-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Marrero, I-
dc.contributor.wosstandardWOS:Deniz, A-
dc.date.coverdateEnero 2004en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.jcr1,782
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-3732-9929-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMarrero Arencibia, María Isabel-
Colección:Artículos
Vista resumida

Citas SCOPUSTM   

3
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

2
actualizado el 25-feb-2024

Visitas

57
actualizado el 24-feb-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.