Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44735
Campo DC Valoridioma
dc.contributor.authorZumbado, Manuel
dc.contributor.authorLuzardo, Octavio P.
dc.contributor.authorLara, Pedro C.
dc.contributor.authorÁlvarez-León, Eva E.
dc.contributor.authorLosada, Antonio
dc.contributor.authorApolinario, Rosa
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorBoada, Luis D.
dc.contributor.otherZumbado, Manuel
dc.contributor.otherDominguez-Boada, Luis
dc.contributor.otherP. Luzardo, Octavio
dc.contributor.otherSerra-Majem, Lluis
dc.date.accessioned2018-11-22T02:06:07Z-
dc.date.available2018-11-22T02:06:07Z-
dc.date.issued2010
dc.identifier.issn1096-6374
dc.identifier.urihttp://hdl.handle.net/10553/44735-
dc.description.abstractContext: Serum levels of Insulin-like growth factor I (IGIF-I) play a critical role in children growth and in the pathogenesis of several diseases. In addition, recent Studies suggest that DDT-derivative organochlorine pesticides (OC-DDTs) could influence IGF levels in human beings.Objective and design: Because it has been suggested that IGF-I peak levels at puberty could determine IGF-I levels in adulthood, we developed a cross-sectional study of the potential association between serum levels of OC-DDTs and IGF system in 160 serum samples from young people (81 boys and 79 girls) living in the Canary Islands (Spain).Results: Multivariate tests were used adjusting for confounding variables (age, height, and weight) and stratifying by gender and age: IGF-I serum levels were significantly lower in pre-pubertal male children (6-15 years) who showed detectable Values of p,p'-DDE, and p,p'-DDD than in pre-pubertal male children with undetectable levels of these OC-DDT's-metabolites (p = 0.023 and p = 0.049, respectively). In addition, in this multivariate model, a non-linear dose-response curve was observed between Total DDT body burden (sum of the three DDT-derivatives measured: p,p'-DDT, p,p'-DDE, and p,p'-DDD) and IGF-I in prepubertal male children (6-15 years; p = 0.043).Conclusion: These findings Suggest that OC-DDTs Could modulate the IGF-system in a way that is highly influenced by gender and age. Improvements in our understanding of exogenous determinants of the IGF-system may provide new insights into the role played by environmental contaminants in IGF-related diseases. (C) 2009 Elsevier Ltd. All rights reserved.
dc.publisher1096-6374
dc.relation.ispartofGrowth Hormone and IGF Research
dc.sourceGrowth Hormone and IGF Research[ISSN 1096-6374],v. 20, p. 63-67
dc.subject.otherBinding Protein-3 Igfbp-3
dc.subject.otherBreast-Cancer
dc.subject.otherHormone
dc.subject.otherExposure
dc.subject.otherRisk
dc.subject.otherSex
dc.subject.otherAge
dc.subject.otherAssociations
dc.subject.otherPollutants
dc.subject.otherEstrogens
dc.titleInsulin-like growth factor-I (IGF-I) serum concentrations in healthy children and adolescents: Relationship to level of contamination by DDT-derivative pesticides
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.ghir.2009.07.003
dc.identifier.scopus74649085192-
dc.identifier.isi000274959300009
dcterms.isPartOfGrowth Hormone & Igf Research
dcterms.sourceGrowth Hormone & Igf Research[ISSN 1096-6374],v. 20 (1), p. 63-67
dc.contributor.authorscopusid6603459604
dc.contributor.authorscopusid6507534124
dc.contributor.authorscopusid7004374085
dc.contributor.authorscopusid6603324897
dc.contributor.authorscopusid16223508500
dc.contributor.authorscopusid6602891555
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid6603916807
dc.description.lastpage67
dc.description.firstpage63
dc.relation.volume20
dc.type2Artículoes
dc.identifier.wosWOS:000274959300009
dc.contributor.daisngid418822
dc.contributor.daisngid418704
dc.contributor.daisngid591076
dc.contributor.daisngid1848250
dc.contributor.daisngid1043283
dc.contributor.daisngid3222931
dc.contributor.daisngid28836
dc.contributor.daisngid697526
dc.identifier.investigatorRIDB-4495-2010
dc.identifier.investigatorRIDL-5577-2015
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Zumbado, M
dc.contributor.wosstandardWOS:Luzardo, OP
dc.contributor.wosstandardWOS:Lara, PC
dc.contributor.wosstandardWOS:Alvarez-Leon, EE
dc.contributor.wosstandardWOS:Losada, A
dc.contributor.wosstandardWOS:Apolinario, R
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Boada, LD
dc.date.coverdateFebrero 2010
dc.identifier.ulpgces
dc.description.jcr2,229
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
crisitem.author.fullNameApolinario Hidalgo, Rosa María-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.author.fullNameDomínguez Boada, Luis María-
Colección:Artículos
Vista resumida

Citas SCOPUSTM   

24
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

22
actualizado el 25-feb-2024

Visitas

51
actualizado el 24-feb-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.