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Title: Dietary methods and biomarkers of omega 3 fatty acids: A systematic review
Authors: Serra-Majem, Lluis 
Nissensohn, Mariela 
Øverby, Nina C.
Fekete, Katalin
UNESCO Clasification: 3206 Ciencias de la nutrición
Keywords: Fatty-Acid-Composition
Food Frequency Questionnaire
Cardiovascular Risk-Factors
Gamma-Linolenic Acid
Plasma-Lipid Levels, et al
Issue Date: 2012
Publisher: 0007-1145
Journal: British Journal of Nutrition 
Abstract: The aims of the present study were to review the validity of dietary methods used to measure the usual long chain (LC) omega-3 polyunsaturated fatty acid (n-3 PUFA) intake of a population and to assess the usefulness of different biomarkers of n-3 PUFA in healthy humans. Two systematic literature searches were conducted until May 2011 to update previous systematic reviews. The first literature search aimed to find studies validating the methodology used for measuring the dietary intake of n-3 PUFA. The second search aimed to find human intervention studies in which n-3 PUFA status changed after 2 weeks of n-3 PUFA supplementation. Sixteen studies were identified for inclusion in the first review. Correlation coefficients between fatty acids in subcutaneous fat or blood lipids and dietary intake of n-3 PUFA from different questionnaires were similar. Subcutaneous fat has been reported as the best reference method for some authors, and these studies showed moderate correlation coefficients with no dietary intake method being superior to any other. As for the evaluation of biomarkers of docosahexaenoic acid (DHA, 22 : 6 n-3) and eicosapentaenoic acid (EPA, 20 : 5n-3) status in response to supplementation, the new search reaffirmed and reinforced the evidence supporting that plasma phospholipid DHA, erythrocyte DHA, and platelet DHA were all effective and robust biomarkers of DHA status. Our findings only confirmed earlier studies and did not provide evidence for reaching new conclusions. © 2012 The Authors.
ISSN: 0007-1145
DOI: 10.1017/S000711451200147X
Source: British Journal of Nutrition[ISSN 0007-1145],v. 107
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