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Title: Effect of zinc intake on serum/plasma zinc status in infants: A meta-analysis
Authors: Nissensohn, Mariela 
Sánchez Villegas, Almudena 
Fuentes Lugo, Daniel
Henríquez Sánchez, Patricia 
Doreste Alonso, Jorge Luis 
Lowe, Nicola M.
Hall Moran, Victoria
Skinner, Anna Louise
Warthon Medina, Marisol
Serra-Majem, Lluis 
Keywords: Protein-Energy Malnutrition
Dietary Zinc
Supplementation, et al
Issue Date: 2013
Publisher: 1740-8695
Journal: Maternal and Child Nutrition 
Abstract: A systematic review and meta-analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2=98%; P=0.00001). When we performed a meta-regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (PANCOVA=0.054; <0.001 and <0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4-20 weeks and >20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12mgday-1. In all cases, the pooled showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence-based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.
ISSN: 1740-8695
DOI: 10.1111/mcn.12045
Source: Maternal and Child Nutrition[ISSN 1740-8695],v. 9, p. 285-298
Appears in Collections:Reseña
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