Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44679
Title: Effect of zinc intake on serum/plasma zinc status in infants: A meta-analysis
Authors: Nissensohn, Mariela 
Sánchez Villegas, Almudena 
Fuentes Lugo, Daniel
Henríquez Sánchez, Patricia 
Doreste Alonso, Jorge
Lowe, Nicola M.
Hall Moran, Victoria
Skinner, Anna Louise
Warthon Medina, Marisol
Serra-Majem, Lluis 
Keywords: Protein-Energy Malnutrition
Dietary Zinc
Controlled-Trial
Double-Blind
Supplementation
Plasma
Growth
Children
Serum
Iron
Issue Date: 2013
Publisher: 1740-8695
Journal: Maternal and Child Nutrition 
Abstract: A systematic review and meta-analysis of available randomised controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on serum/plasma Zn status in infants. Out of 5500 studies identified through electronic searches and reference lists, 13 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on serum/plasma Zn concentration was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status and risk of bias. The pooled of status was 0.09 [confidence interval (CI) 0.05 to 0.12]. However, a substantial heterogeneity was present in the analyses (I2=98%; P=0.00001). When we performed a meta-regression, the effect of Zn intake on serum/plasma Zn status changed depending on the duration of the intervention, the dose of supplementation and the nutritional situation (PANCOVA=0.054; <0.001 and <0.007, respectively). After stratifying the sample according to the effect modifiers, the results by duration of intervention showed a positive effect when Zn intake was provided during medium and long periods of time (4-20 weeks and >20 weeks). A positive effect was also seen when doses ranged from 8.1 to 12mgday-1. In all cases, the pooled showed high evidence of heterogeneity. Zn supplementation increases serum/plasma Zn status in infants, although high evidence of heterogeneity was found. Further standardised research is urgently needed to reach evidence-based conclusions to clarify the role of Zn supplementation upon infant serum/plasma Zn status, particularly in Europe.
URI: http://hdl.handle.net/10553/44679
ISSN: 1740-8695
DOI: 10.1111/mcn.12045
Source: Maternal and Child Nutrition[ISSN 1740-8695],v. 9, p. 285-298
Appears in Collections:Reseña
Show full item record

SCOPUSTM   
Citations

6
checked on Feb 28, 2021

WEB OF SCIENCETM
Citations

8
checked on Feb 28, 2021

Page view(s)

13
checked on Feb 27, 2021

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.