Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44664
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dc.contributor.authorOrtega-Azorín, Carolina
dc.contributor.authorSorlí, Jose V.
dc.contributor.authorEstruch, Ramón
dc.contributor.authorAsensio, Eva M.
dc.contributor.authorColtell, Oscar
dc.contributor.authorGonzález, José I.
dc.contributor.authorMartínez-González, Miguel Ángel
dc.contributor.authorRos, Emilio
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorFitó, Montserrat
dc.contributor.authorArós, Fernando
dc.contributor.authorLapetra, José
dc.contributor.authorSerra-Majem, Lluís
dc.contributor.authorRuiz-Gutiérrez, Valentina
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorFiol, Miquel
dc.contributor.authorFlores, Gemma
dc.contributor.authorPintó, Xavier
dc.contributor.authorSaiz, Carmen
dc.contributor.authorOrdovás, José M.
dc.contributor.authorCorella, Dolores
dc.date.accessioned2018-11-22T01:28:56Z-
dc.date.available2018-11-22T01:28:56Z-
dc.date.issued2014
dc.identifier.issn1942-325X
dc.identifier.urihttp://hdl.handle.net/10553/44664-
dc.description.abstractBackground: A variant (rs3812316, C771G, and Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. However, its association with cardiovascular diseases and gene-diet interactions modulating these traits are unknown. Methods and Results: We studied 7166 participants in the PREvención with DIeta MEDiterránea trial testing a Mediterranean diet (MedDiet) intervention versus a control diet for cardiovascular prevention, with a median follow-up of 4.8 years. Diet, lipids, MLXIPL polymorphisms, and cardiovascular events were assessed. Data were analyzed at baseline and longitudinally. We used multivariable-adjusted Cox regression to estimate hazard ratios for cardiovascular outcomes. The MLXIPL-rs3812316 was associated with lower baseline triglycerides (P=5.5×10-5) and lower hypertriglyceridemia (odds ratio, 0.73; 95% confidence interval [CI], 0.63-0.85; P=1.4×10-6 in G-carriers versus CC). This association was modulated by baseline adherence to MedDiet. When adherence to MedDiet was high, the protection was stronger (odds ratio, 0.63; 95% CI, 0.51-0.77; P=8.6×10-6) than when adherence to MedDiet was low (odds ratio, 0.88; 95% CI, 0.70-1.09; P=0.219). Throughout the follow-up, both the MLXIPL-rs3812316 (P=3.8×10-6) and the MedDiet intervention (P=0.030) were significantly associated with decreased triglycerides. Likewise in G-carriers MedDiet intervention was associated with greater total cardiovascular risk reduction and specifically for myocardial infarction. In the MedDiet, but not in the control group, we observed lower myocardial infarction incidence in G-carriers versus CC (hazard ratios, 0.34; 95% CI, 0.12-0.93; P=0.036 and 0.90; 95% CI, 0.35-2.33; P=0.830, respectively). Conclusions: Our novel results suggest that MedDiet enhances the triglyceride-lowering effect of the MLXIPL-rs3812316 variant and strengthens its protective effect on myocardial infarction incidence. © 2014 American Heart Association, Inc.
dc.publisher1942-325X
dc.relation.ispartofCirculation: Cardiovascular Genetics
dc.sourceCirculation: Cardiovascular Genetics[ISSN 1942-325X],v. 7, p. 49-58
dc.subject.otherCoronary-Artery-Disease
dc.subject.otherLipid Concentrations
dc.subject.otherInsulin-Resistance
dc.subject.otherHepatic Steatosis
dc.subject.otherMlxipl Gene
dc.subject.otherChrebp
dc.subject.otherLoci
dc.subject.otherPopulation
dc.subject.otherVariant
dc.subject.otherLiver
dc.titleAmino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the mediterranean diet in the PREDIMED trial
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1161/CIRCGENETICS.113.000301
dc.identifier.scopus84898733769-
dc.identifier.isi000331406000009
dc.contributor.authorscopusid21835135600
dc.contributor.authorscopusid7004605575
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid50261129400
dc.contributor.authorscopusid6603090571
dc.contributor.authorscopusid57192590236
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid35474202600
dc.contributor.authorscopusid7003357665
dc.contributor.authorscopusid57208853460
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid7004979765
dc.contributor.authorscopusid57202571697
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid55184396800
dc.contributor.authorscopusid7004430064
dc.contributor.authorscopusid6602702155
dc.contributor.authorscopusid7101791147
dc.contributor.authorscopusid7003570538
dc.description.lastpage58
dc.description.firstpage49
dc.relation.volume7
dc.type2Artículoes
dc.contributor.daisngid31451717
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dc.contributor.daisngid17754
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dc.contributor.daisngid74443
dc.contributor.daisngid106289
dc.contributor.daisngid246378
dc.contributor.daisngid28836
dc.contributor.daisngid124737
dc.contributor.daisngid276771
dc.contributor.daisngid78038
dc.contributor.daisngid1572551
dc.contributor.daisngid115192
dc.contributor.daisngid2580852
dc.contributor.daisngid1564
dc.contributor.daisngid25404
dc.contributor.wosstandardWOS:Ortega-Azorin, C
dc.contributor.wosstandardWOS:Sorli, JV
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Asensio, EM
dc.contributor.wosstandardWOS:Coltell, O
dc.contributor.wosstandardWOS:Gonzalez, JI
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Ruiz-Gutierrez, V
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Flores, G
dc.contributor.wosstandardWOS:Pinto, X
dc.contributor.wosstandardWOS:Saiz, C
dc.contributor.wosstandardWOS:Ordovas, JM
dc.contributor.wosstandardWOS:Corella, D
dc.date.coverdateEnero 2014
dc.identifier.ulpgces
dc.description.jcr4,631
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptCiencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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