Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44636
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dc.contributor.authorMerino, Jordi
dc.contributor.authorGuasch-Ferré, Marta
dc.contributor.authorMartínez-González, Miguel A.
dc.contributor.authorCorella, Dolores
dc.contributor.authorEstruch, Ramon
dc.contributor.authorFitó, Montserrat
dc.contributor.authorRos, Emilio
dc.contributor.authorArós, Fernando
dc.contributor.authorBulló, Mònica
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorMoñino, Manuel
dc.contributor.authorLapetra, José
dc.contributor.authorSerra-Majem, Lluís
dc.contributor.authorRazquin, Cristina
dc.contributor.authorBuil-Cosiales, Pilar
dc.contributor.authorSorlí, José V.
dc.contributor.authorMuñoz, Miguel A.
dc.contributor.authorPintó, Xavier
dc.contributor.authorMasana, Luis
dc.contributor.authorSalas-Salvadó, Jordi
dc.date.accessioned2018-11-22T01:15:16Z-
dc.date.available2018-11-22T01:15:16Z-
dc.date.issued2015
dc.identifier.issn0002-9165
dc.identifier.urihttp://hdl.handle.net/10553/44636-
dc.description.abstractBackground: Excess sodium intake is associated with high blood pressure, a major risk factor for cardiovascular disease (CVD). It is unknown whether decreasing sodium intake to <2300 mg/d has an effect on CVD or all-cause mortality.Objective: The objective was to assess whether reductions in sodium intake to <2300 mg/d were associated with either an increased or a decreased risk of fatal and nonfatal CVD and all-cause mortality.Design: This observational prospective study of the PREvencion con DIeta MEDiterranea (PREDIMED) trial included 3982 participants at high CVD risk. Sodium intake was evaluated with a validated food-frequency questionnaire and categorized as low (<1500 mg/d), intermediate (>= 1500 to <= 2300 mg/d), high (>2300 to <= 3400 mg/d), or very high (>3400 mg/d). Subsequently, 1-y and 3-y changes in sodium intake were calculated. Multivariate relative risks were assessed by using Cox proportional hazards ratios. Marginal structural models with inverse probability weighting were used to test the effect of changes in sodium intake and the Mediterranean diet (MedDiet).Results: We documented 125 CVD events and 131 deaths after a 4.8-y median follow-up. Sodium intake <2300 mg/d was associated with a lower risk of all-cause mortality: 48% (HR: 0.52; 95% CI: 0.30, 0.91; P = 0.02) and 49% (HR: 0.51; 95% CI: 0.26, 0.98; P = 0.04) after 1 and 3 y, respectively. Increasing sodium intake after 1 y was associated with a 72% (HR: 1.72; 95% CI: 1.01, 2.91; P = 0.04) higher risk of CVD events. The incidence rate of CVD was reduced for those who reduced their sodium intake and were randomly assigned to MedDiet interventions [4.1/10,000 (95% CI: 3.1, 8.0) compared with 4.4/10,000 (95% CI: 2.7, 12.4) person-years; P = 0.0021.Conclusions: Decreasing sodium intake to <2300 mg/d was associated with a reduced risk of all-cause mortality, whereas increasing the intake to >2300 mg/d was associated with a higher risk of CVD. Our observational data suggest that sodium intake <2300 mg/d was associated with an enhanced beneficial effect of the MedDiet on CVD. These results should be interpreted with caution, and other confirmatory studies are necessary.
dc.publisher0002-9165
dc.relation.ispartofThe American journal of clinical nutrition
dc.sourceAmerican Journal of Clinical Nutrition[ISSN 0002-9165],v. 101, p. 440-448
dc.subject.otherBlood-Pressure
dc.subject.otherUrinary Sodium
dc.subject.otherPotassium Excretion
dc.subject.otherMediterranean Diet
dc.subject.otherPrimary Prevention
dc.subject.otherDash Diet
dc.subject.otherDisease
dc.subject.otherPopulation
dc.subject.otherHypertension
dc.subject.otherQuestionnaire
dc.titleIs complying with the recommendations of sodium intake beneficial for health in individuals at high cardiovascular risk? Findings from the PREDIMED study
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.3945/ajcn.114.096750
dc.identifier.scopus84928416462-
dc.identifier.isi000350538800006
dc.contributor.authorscopusid36239337400
dc.contributor.authorscopusid55110459200
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid35474202600
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid6602243634
dc.contributor.authorscopusid57202571697
dc.contributor.authorscopusid14120071900
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid13612519200
dc.contributor.authorscopusid26029100700
dc.contributor.authorscopusid7004605575
dc.contributor.authorscopusid57199669354
dc.contributor.authorscopusid57207272093
dc.contributor.authorscopusid7004430064
dc.contributor.authorscopusid13805771600
dc.contributor.authorscopusid7003357665
dc.description.lastpage448
dc.description.firstpage440
dc.relation.volume101
dc.type2Artículoes
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dc.contributor.daisngid845551
dc.contributor.daisngid1132156
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dc.contributor.daisngid44898
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dc.contributor.wosstandardWOS:Merino, J
dc.contributor.wosstandardWOS:Guasch-Ferre, M
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Ros, E
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Bullo, M
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Monino, M
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Razquin, C
dc.contributor.wosstandardWOS:Buil-Cosiales, P
dc.contributor.wosstandardWOS:Sorli, JV
dc.contributor.wosstandardWOS:Munoz, MA
dc.contributor.wosstandardWOS:Pinto, X
dc.contributor.wosstandardWOS:Masana, L
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.date.coverdateEnero 2015
dc.identifier.ulpgces
dc.description.sjr4,06
dc.description.jcr6,703
dc.description.sjrqQ1
dc.description.jcrqQ1
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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