Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44615
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dc.contributor.authorDiaz-Ĺopez, Andrés
dc.contributor.authorBabio, Nancy
dc.contributor.authorMartinez-González, Miguel A.
dc.contributor.authorCorella, Dolores
dc.contributor.authorAmor, Antonio J.
dc.contributor.authorFitó, Montse
dc.contributor.authorEstruch, Ramon
dc.contributor.authorAŕos, Fernando
dc.contributor.authorǴomez-Gracia, Enrique
dc.contributor.authorFiol, Miquel
dc.contributor.authorLapetra, José
dc.contributor.authorSerra-Majem, Llúis
dc.contributor.authorBasora, Josep
dc.contributor.authorBasterra-Gortari, F. Javier
dc.contributor.authorZanon-Moreno, Vicente
dc.contributor.authorMunoz, Miguel Angel
dc.contributor.authorO, Jordi Salas Salvad
dc.date.accessioned2018-11-22T01:05:06Z-
dc.date.available2018-11-22T01:05:06Z-
dc.date.issued2015
dc.identifier.issn0149-5992
dc.identifier.urihttp://hdl.handle.net/10553/44615-
dc.description.abstractOBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet.RESEARCH DESIGN AND METHODSThis was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvencion con Dleta MEDiterranea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), Med Diet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression.RESULTSDuring a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the Med Diet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy.CONCLUSIONSA Med Diet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
dc.publisher0149-5992
dc.relation.ispartofDiabetes Care
dc.sourceDiabetes Care[ISSN 0149-5992],v. 38, p. 2134-2141
dc.subject.otherKidney-Function
dc.subject.otherSubgroup Analysis
dc.subject.otherStyle Diet
dc.subject.otherOlive Oil
dc.subject.otherFruit
dc.subject.otherAssociations
dc.subject.otherAlbuminuria
dc.subject.otherValidation
dc.subject.otherPrevention
dc.subject.otherPatterns
dc.titleMediterranean diet, retinopathy, nephropathy, and microvascular diabetes Complications: A post Hoc analysis of a randomized trial
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.2337/dc15-1117
dc.identifier.scopus84962373589-
dc.identifier.isi000364342500034
dc.contributor.authorscopusid55195487000
dc.contributor.authorscopusid24279242400
dc.contributor.authorscopusid56200287800
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid7003570538
dc.contributor.authorscopusid54419413900
dc.contributor.authorscopusid57202558934
dc.contributor.authorscopusid6602891390
dc.contributor.authorscopusid7005989830
dc.contributor.authorscopusid7004158382
dc.contributor.authorscopusid57188706001
dc.contributor.authorscopusid7005315313
dc.contributor.authorscopusid6507771144
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid23017786300
dc.contributor.authorscopusid16306349400
dc.contributor.authorscopusid8385653800
dc.contributor.authorscopusid57207272093
dc.contributor.authorscopusid57199669354
dc.contributor.authorscopusid57188699925
dc.description.lastpage2141
dc.description.firstpage2134
dc.relation.volume38
dc.type2Artículoes
dc.contributor.daisngid2159150
dc.contributor.daisngid691402
dc.contributor.daisngid17754
dc.contributor.daisngid25404
dc.contributor.daisngid1754006
dc.contributor.daisngid74443
dc.contributor.daisngid19357
dc.contributor.daisngid106289
dc.contributor.daisngid276771
dc.contributor.daisngid78038
dc.contributor.daisngid34937322
dc.contributor.daisngid28836
dc.contributor.daisngid348215
dc.contributor.daisngid1014738
dc.contributor.daisngid1366949
dc.contributor.daisngid9921613
dc.contributor.daisngid25605
dc.contributor.wosstandardWOS:Diaz-Lopez, A
dc.contributor.wosstandardWOS:Babio, N
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Corella, D
dc.contributor.wosstandardWOS:Amor, AJ
dc.contributor.wosstandardWOS:Fito, M
dc.contributor.wosstandardWOS:Estruch, R
dc.contributor.wosstandardWOS:Aros, F
dc.contributor.wosstandardWOS:Gomez-Gracia, E
dc.contributor.wosstandardWOS:Fiol, M
dc.contributor.wosstandardWOS:Lapetra, J
dc.contributor.wosstandardWOS:Serra-Majem, L
dc.contributor.wosstandardWOS:Basora, J
dc.contributor.wosstandardWOS:Basterra-Gortari, FJ
dc.contributor.wosstandardWOS:Zanon-Moreno, V
dc.contributor.wosstandardWOS:Munoz, MA
dc.contributor.wosstandardWOS:Salas-Salvado, J
dc.date.coverdateNoviembre 2015
dc.identifier.ulpgces
dc.description.sjr5,764
dc.description.jcr8,934
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
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