Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44605
Campo DC Valoridioma
dc.contributor.authorDowner, Mary K.en_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorGea, Alfredoen_US
dc.contributor.authorStampfer, Meiren_US
dc.contributor.authorWarnberg, Juliaen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorFitó, Montseen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorSerra-Majem, Lluísen_US
dc.contributor.authorBullo, Monicaen_US
dc.contributor.authorSorli, Jose V.en_US
dc.contributor.authorMuñoz, Miguel A.en_US
dc.contributor.authorGarcía-Rodriguez, Antonioen_US
dc.contributor.authorGutierrez-Bedmar, Marioen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.date.accessioned2018-11-22T01:00:01Z-
dc.date.available2018-11-22T01:00:01Z-
dc.date.issued2017en_US
dc.identifier.issn1471-2261en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/44605-
dc.description.abstractBackground: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail mercury concentration. In-person interviews, medical record reviews and validated questionnaires were used to assess fish consumption and other covariates. Information was collected at baseline and updated yearly during follow-up. We used conditional logistic regression to evaluate associations in the total nested case-control study, and unconditional logistic regression for population subsets. Results: Mean (±SD) toenail mercury concentrations (μg per gram) did not significantly differ between cases (0.63 (±0.53)) and controls (0.67 (±0.49)). Mercury concentration was not associated with cardiovascular disease in any analysis, and neither was fish consumption or n-3 fatty acids. The fully-adjusted relative risks for the highest versus lowest quartile of mercury concentration were 0.71 (95% Confidence Interval [CI], 0.34, 1.14; ptrend=0.37) for the nested case-control study, 0.74 (95% CI, 0.32, 1.76; ptrend=.43) within the Mediterranean diet intervention group, and 0.50 (95% CI, 0.13, 1.96; ptrend=0.41) within the control arm of the trial. Associations remained null when mercury was jointly assessed with fish consumption at baseline and during follow-up. Results were similar in different sensitivity analyses. Conclusions: We found no evidence that mercury exposure from regular fish consumption increases cardiovascular disease risk in a population of Spanish adults with high cardiovascular disease risk and high fish consumption. This implies that the mercury content in fish does not detract from the already established cardiovascular benefits of fish consumption.en_US
dc.languageengen_US
dc.relationRed Alimentación Saludable en la Prevención Primaria de Enfermedades Crónicas: la Red Predimed. (Retics 2006)en_US
dc.relation.ispartofBMC Cardiovascular Disordersen_US
dc.sourceBmc Cardiovascular Disorders [ISSN 1471-2261], v. 17, (Enero 2017)en_US
dc.subject320501 Cardiologíaen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCoronary-Heart-Diseaseen_US
dc.subject.otherFood-Frequency Questionnaireen_US
dc.subject.otherMeat Consumptionen_US
dc.subject.otherHuman Healthen_US
dc.subject.otherFish Intakeen_US
dc.subject.otherMethylmercury Exposureen_US
dc.subject.otherMyocardial-Infarctionen_US
dc.subject.otherMortalityen_US
dc.subject.otherMenen_US
dc.subject.otherPatternsen_US
dc.subject.otherMercuryen_US
dc.subject.otherFishen_US
dc.subject.otherCardiovascular Diseaseen_US
dc.subject.otherMediterranean Dieten_US
dc.subject.otherPredimeden_US
dc.subject.otherToenail Biomarkeren_US
dc.titleMercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) studyen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12872-016-0435-8en_US
dc.identifier.scopus85008319279-
dc.identifier.isi000391341100007-
dc.contributor.authorscopusid57188728417-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid55341244700-
dc.contributor.authorscopusid55541278700-
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dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid6602243634-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid57207272093-
dc.contributor.authorscopusid7003580536-
dc.contributor.authorscopusid6506505275-
dc.contributor.authorscopusid57202571697-
dc.identifier.issue9-
dc.relation.volume17en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2271002-
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dc.description.numberofpages11en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Downer, MK-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.contributor.wosstandardWOS:Gea, A-
dc.contributor.wosstandardWOS:Stampfer, M-
dc.contributor.wosstandardWOS:Warnberg, J-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Bullo, M-
dc.contributor.wosstandardWOS:Sorli, JV-
dc.contributor.wosstandardWOS:Munoz, MA-
dc.contributor.wosstandardWOS:Garcia-Rodriguez, A-
dc.contributor.wosstandardWOS:Gutierrez-Bedmar, M-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.date.coverdateEnero 2017en_US
dc.identifier.ulpgces
dc.description.sjr0,909
dc.description.jcr1,812
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.project.principalinvestigatorSerra Majem, Luis-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
miniatura
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