Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44547
Título: Experience in the treatment of cutaneous in-transit melanoma metastases and satellitosis with intralesional interleukin-2
Autores/as: Dehesa, L. A.
Vilar-Alejo, J.
Valerón-Almazán, P. 
Carretero, G.
Clasificación UNESCO: 52 Demografía
Fecha de publicación: 2009
Editor/a: 0001-7310
Publicación seriada: Actas dermo-sifiliográficas (Ed. impresa) 
Resumen: Although metastatic melanoma has a poor prognosis, cutaneous metastases represent a special case given their ready accessibility, making it possible for dermatologists to apply local treatment. We report our experience with intralesional treatment with interleukin (IL) 2 in 7 patients with cutaneous metastases from malignant melanoma. A total of 244 lesions in 7 patients with satellitosis and/or cutaneous metastases from malignant melanoma were treated with intralesional IL-2 twice a week. The maximum dose in each patient ranged from 3 to 18 million units per session, according to the number and size of lesions. Complete or partial remission was achieved in almost all lesions (95.9 % and 3.7 %, respectively).Only 1 lesion (0.4 %) -the largest and located subcutaneously- did not respond to intralesional treatment and required alcoholization and subsequent surgical removal to achieve cure. All partial responses occurred in subcutaneous lesions larger than 2 cm. Treatment was well tolerated with only a few mild side effects (grade 1-2). IL-2 may be an effective and well-tolerated treatment option in patients with satellitosis and cutaneous metastases from melanoma. Lesions smaller than 2 cm and located in the epidermis or superficial dermis respond better than those larger than 2 cm or located in the subcutaneous cellular tissue. More studies are necessary to establish appropriate doses and regimens.
URI: http://hdl.handle.net/10553/44547
ISSN: 0001-7310
DOI: 10.1016/S0001-7310(09)71905-2
Fuente: Actas Dermo-Sifiliograficas[ISSN 0001-7310],v. 100, p. 571-585
Colección:Artículos
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