Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44476
Título: Free radicals and sprint exercise in humans
Autores/as: Morales-Alamo, D. 
Calbet, J. A L 
Clasificación UNESCO: 241106 Fisiología del ejercicio
Palabras clave: Antioxidant, Exercise, Reactive oxygen species, Redox signaling, Xanthine dehydrogenase/xanthine oxidase
Fecha de publicación: 2014
Editor/a: 1071-5762
Publicación seriada: Free Radical Research 
Resumen: Sprint exercise ability has been critical for survival. The remarkably high-power output levels attained during sprint exercise are achieved through strong activation of anaerobic, and to a lesser extent, aerobic energy supplying metabolic reactions, which generate reactive oxygen and nitrogen species (RONS). Sprint exercise may cause oxidative stress leading to muscle damage, particularly when performed in severe acute hypoxia. However, with training oxidative stress is reduced. Paradoxically, total plasma antioxidant capacity increases during the subsequent 2 h after a short sprint due to the increase in plasma urate concentration. The RONS produced during and immediately after sprint exercise play a capital role in signaling the adaptive response to sprint. Antioxidant supplementation blunts the normal AMPKα and CaMKII phosphorylation in response to sprint exercise. However, under conditions of increased glycolytic energy turnover and muscle acidification, as during sprint exercise in severe acute hypoxia, AMPKα phosphorylation is also blunted. This indicates that an optimal level of RONS-mediated stimulation is required for the normal signaling response to sprint exercise. Although RONS are implicated in fatigue, most studies convey that antioxidants do not enhance sprint performance in humans. Although currently controversial, it has been reported that antioxidant ingestion during training may jeopardize some of the beneficial adaptations to sprint training.
URI: http://hdl.handle.net/10553/44476
ISSN: 1071-5762
DOI: 10.3109/10715762.2013.825043
Fuente: Free Radical Research[ISSN 1071-5762],v. 48, p. 30-42
Colección:Reseña
Vista completa

Citas SCOPUSTM   

64
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

62
actualizado el 25-feb-2024

Visitas

19
actualizado el 03-sep-2022

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.