Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/44461
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dc.contributor.authorCastro López-Tarruella, Enriqueen_US
dc.contributor.authorOset‐Gasque, M. J.en_US
dc.contributor.authorCañadas, S.en_US
dc.contributor.authorGimenez, G.en_US
dc.contributor.authorGonzález, M. P.en_US
dc.date.accessioned2018-11-21T23:15:17Z-
dc.date.available2018-11-21T23:15:17Z-
dc.date.issued1988en_US
dc.identifier.issn0360-4012en_US
dc.identifier.urihttp://hdl.handle.net/10553/44461-
dc.description.abstractThe effect of several ligands and Ca2+ ions on [3H]GABA binding to bovine adrenal medulla membranes was investigated. Without any blockade, the [3H]GABA binding showed two components, one of low affinity (Kd = 139 ± 22 nM and Bmax = 3.2 ± 0.4 pmol/mg protein) and the other of high affinity (Kd = 41 ± 6 nM and Bmax = 0.35 ± 0.26 pmol/mg protein). Muscimol specifically blocked low‐affinity sites, and ( – )baclofen blocked high‐affinity components. Ca2+ ions were strictly necessary for maximum binding to high‐affinity sites, whereas they did not significantly affect sites of the lower affinity. These results show that the bovine adrenal medulla has a GABAA receptor population of low affinity together with a GABAB receptor of high affinity.en_US
dc.languageengen_US
dc.publisher0360-4012
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.sourceJournal of Neuroscience Research [ISSN 0360-4012], v. 20, p. 241-245en_US
dc.subject320502 Endocrinologíaen_US
dc.subject240104 Citología animalen_US
dc.subject241003 Citología humanaen_US
dc.subject.otherGABA receptoren_US
dc.subject.otherAdrenal medullaen_US
dc.titleGABAA and GABAB sites in bovine adrenal medulla membranesen_US
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.doi10.1002/jnr.490200213en_US
dc.identifier.scopus0023821306-
dc.contributor.authorscopusid35095882100-
dc.contributor.authorscopusid7004173468-
dc.contributor.authorscopusid6504022975-
dc.contributor.authorscopusid36764277300-
dc.contributor.authorscopusid7404553950-
dc.description.lastpage245-
dc.description.firstpage241-
dc.relation.volume20-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.fullNameCastro López-Tarruella, Enrique-
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