Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44416
DC FieldValueLanguage
dc.contributor.authorA-Gonzalez, Noeliaen_US
dc.contributor.authorBensinger, Steven J.en_US
dc.contributor.authorHong, Cynthiaen_US
dc.contributor.authorBeceiro Casas, Susanaen_US
dc.contributor.authorBradley, Michelle N.en_US
dc.contributor.authorZelcer, Noamen_US
dc.contributor.authorDeniz, Joseen_US
dc.contributor.authorRamirez, Cristinaen_US
dc.contributor.authorDíaz, Mercedesen_US
dc.contributor.authorGallardo Campos, Germánen_US
dc.contributor.authorRuiz de Galarreta, Carlosen_US
dc.contributor.authorSalazar, Jonen_US
dc.contributor.authorLópez Blanco, Félixen_US
dc.contributor.authorEdwards, Peteren_US
dc.contributor.authorParks, Johnen_US
dc.contributor.authorAndujar, Miguelen_US
dc.contributor.authorTontonoz, Peteren_US
dc.contributor.authorCastrillo Viguera, Antonio Jesúsen_US
dc.date.accessioned2018-11-21T22:53:36Z-
dc.date.available2018-11-21T22:53:36Z-
dc.date.issued2009en_US
dc.identifier.issn1074-7613en_US
dc.identifier.urihttp://hdl.handle.net/10553/44416-
dc.description.abstractEffective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly defined. We demonstrate here that LXR signaling is important for both apoptotic cell clearance and the maintenance of immune tolerance. Apoptotic cell engulfment activates LXR and thereby induces the expression of Mer, a receptor tyrosine kinase critical for phagocytosis. LXR null macrophages exhibit a selective defect in phagocytosis of apoptotic cells and an aberrant pro-inflammatory response to them. As a consequence of these defects, mice lacking LXRs manifest a breakdown in self-tolerance and develop autoantibodies and autoimmune glomerulonephritis. Treatment with an LXR agonist ameliorates disease progression in mouse models of Lupus-like autoimmunity. Thus, activation of LXR by apoptotic cells engages a virtuous cycle that promotes their own clearance and couples engulfment to the suppression of inflammatory pathways.en_US
dc.languageengen_US
dc.publisher1074-7613-
dc.relationSaf2005-03270. Los Receptores Lxr y Su Papel en la Respuesta Inflamatoria, Inmunitaria y Apoptótica.en_US
dc.relation.ispartofImmunityen_US
dc.sourceImmunity [ISSN 1074-7613], v. 31, p. 245-258en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherLiver-X-Receptors
dc.subject.otherMer Tyrosine Kinase
dc.subject.otherMice Lacking
dc.subject.otherPhosphatidylserine Receptor
dc.subject.otherSignaling Pathways
dc.subject.otherCholesterol Efflux
dc.subject.otherLipid-Metabolism
dc.subject.otherTam Receptors
dc.subject.otherIn-Vitro
dc.subject.otherPhagocytosis
dc.titleApoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXRen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.immuni.2009.06.018en_US
dc.identifier.scopus68949145931-
dc.identifier.isi000269338600011-
dc.contributor.authorscopusid28567533000-
dc.contributor.authorscopusid6602800046-
dc.contributor.authorscopusid15755660400-
dc.contributor.authorscopusid35084862100-
dc.contributor.authorscopusid7202096772-
dc.contributor.authorscopusid6603239870-
dc.contributor.authorscopusid25421518600-
dc.contributor.authorscopusid8956417600-
dc.contributor.authorscopusid35084829700-
dc.contributor.authorscopusid6603046608-
dc.contributor.authorscopusid7003806034-
dc.contributor.authorscopusid26434849100-
dc.contributor.authorscopusid6602478628-
dc.contributor.authorscopusid7202047893-
dc.contributor.authorscopusid35462789800-
dc.contributor.authorscopusid7202673747-
dc.contributor.authorscopusid7004631953-
dc.contributor.authorscopusid7007079890-
dc.contributor.authorscopusid55445301000-
dc.description.lastpage258en_US
dc.description.firstpage245en_US
dc.relation.volume31en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid34354606-
dc.contributor.daisngid675311-
dc.contributor.daisngid750105-
dc.contributor.daisngid3913413-
dc.contributor.daisngid2210915-
dc.contributor.daisngid569342-
dc.contributor.daisngid6066784-
dc.contributor.daisngid504866-
dc.contributor.daisngid5756470-
dc.contributor.daisngid7801524-
dc.contributor.daisngid1664323-
dc.contributor.daisngid5178367-
dc.contributor.daisngid2864371-
dc.contributor.daisngid28125781-
dc.contributor.daisngid13339-
dc.contributor.daisngid990803-
dc.contributor.daisngid103250-
dc.contributor.daisngid225640-
dc.contributor.wosstandardWOS:A-Gonzalez, N-
dc.contributor.wosstandardWOS:Bensinger, SJ-
dc.contributor.wosstandardWOS:Hong, C-
dc.contributor.wosstandardWOS:Beceiro, S-
dc.contributor.wosstandardWOS:Bradley, MN-
dc.contributor.wosstandardWOS:Zelcer, N-
dc.contributor.wosstandardWOS:Deniz, J-
dc.contributor.wosstandardWOS:Ramirez, C-
dc.contributor.wosstandardWOS:Diaz, M-
dc.contributor.wosstandardWOS:Gallardo, G-
dc.contributor.wosstandardWOS:de Galarreta, CR-
dc.contributor.wosstandardWOS:Salazar, J-
dc.contributor.wosstandardWOS:Lopez, F-
dc.contributor.wosstandardWOS:Edwards, P-
dc.contributor.wosstandardWOS:Parks, J-
dc.contributor.wosstandardWOS:Andujar, M-
dc.contributor.wosstandardWOS:Tontonoz, P-
dc.contributor.wosstandardWOS:Castrillo, A-
dc.date.coverdateAgosto 2009en_US
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Didácticas Específicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3878-3867-
crisitem.author.orcid0000-0002-4858-6915-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBeceiro Casas, Susana-
crisitem.author.fullNameDiaz Cabrera, Moises-
crisitem.author.fullNameGallardo Campos, Germán-
crisitem.author.fullNameLópez Blanco, Félix-
crisitem.author.fullNameAndujar Sanchez, Miguel-
crisitem.author.fullNameCastrillo Viguera, Antonio Jesús-
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