Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/44129
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dc.contributor.authorStoll, A. L.en_US
dc.contributor.authorSuárez-Bonnet, A.en_US
dc.contributor.authorSummers, B. A.en_US
dc.contributor.authorPriestnall, S. L.en_US
dc.date.accessioned2018-11-21T20:27:02Z-
dc.date.available2018-11-21T20:27:02Z-
dc.date.issued2018en_US
dc.identifier.issn0021-9975en_US
dc.identifier.urihttp://hdl.handle.net/10553/44129-
dc.description.abstractDivergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only been reported once (in a dog). Incisional wedge biopsy of a locally extensive, ventral abdominal wall mass, which extended from the dermis to the subcutis, from a 12-year-old female domestic shorthaired cat, was performed. The tissue was examined with routine haematoxylin and eosin staining and immunohistochemical methods. A malignant neoplasm with spindle and polygonal cell components and progression towards a rhabdomyosarcomatous phenotype was observed. Both neoplastic cell populations exhibited strong expression of vimentin and there was multifocal expression of S100 and desmin. There was strong cytoplasmic labelling for α-sarcomeric actin and muscle actin and weak labelling for myoglobin within the cells positive for desmin. There was multifocal positive nuclear labelling for myogenin. Glial fibrillary acidic protein, α-smooth muscle actin, microphthalmia-associated transcription factor and melanoma antigen recognized by T cells were not expressed. Microscopical features, aided by immunohistochemistry, identified a MPNST with progression towards a rhabdomyosarcomatous phenotype, a so-called ‘triton tumour’. A Schwann cell component could account for the divergent patterns of growth, given the plasticity of the neural crest. Nerve sheath tumours have been reported in the skin and subcutis of cats and are a differential diagnosis of feline cutaneous spindle cell neoplasms.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Comparative Pathologyen_US
dc.sourceJournal of Comparative Pathology [ISSN 0021-9975], v. 165, p. 1-5en_US
dc.subject3109 Ciencias veterinariasen_US
dc.subject.otherCaten_US
dc.subject.otherPeripheral nerve sheath tumouren_US
dc.subject.otherRhabdomyosarcomatous differentiationen_US
dc.subject.otherTriton tumouren_US
dc.titleMalignant cutaneous peripheral nerve sheath tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a domestic caten_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jcpa.2018.09.003en_US
dc.identifier.scopus85055054620-
dc.contributor.authorscopusid36482201200-
dc.contributor.authorscopusid25636181300-
dc.contributor.authorscopusid57204242656-
dc.contributor.authorscopusid6508041786-
dc.description.lastpage5en_US
dc.description.firstpage1en_US
dc.relation.volume165en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.sjr0,561
dc.description.jcr1,249
dc.description.sjrqQ2
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameSuarez Bonnet,Alejandro-
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