Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43848
DC FieldValueLanguage
dc.contributor.authorBordón Rodríguez, Elisa de los Reyesen_US
dc.contributor.authorHenríquez Hernández, Luis Albertoen_US
dc.contributor.authorLara, Pedro Carlosen_US
dc.contributor.authorPinar, Beatrizen_US
dc.contributor.authorRodríaguez-Gallego, Carlosen_US
dc.contributor.authorLloret Sáez-Bravo, Martaen_US
dc.date.accessioned2018-11-21T18:18:14Z-
dc.date.available2018-11-21T18:18:14Z-
dc.date.issued2011en_US
dc.identifier.issn0955-3002en_US
dc.identifier.urihttp://hdl.handle.net/10553/43848-
dc.description.abstractPurpose: To analyse the role of in vitro radio-induced apoptosis of lymphocyte subpopulations as predictive test for late effects in cervical cancer patients treated with radiotherapy. Methods and materials: Ninety-four consecutive patients and four healthy controls were included in the study. Toxicity was evaluated using the Late Effects Normal Tissue-Subjective, Objective, Management, and Analytic (LENT-SOMA) scale. Peripheral blood lymphocyte subpopulations were isolated and irradiated at 0, 1, 2 and 8 Gy, and then collected 24, 48 and 72 h after irradiation. Apoptosis was measured by flow cytometry. Results: Radiation-induced apoptosis increased with radiation dose and time of incubation, and data fitted to a semi-logarithmic model defined by two constants: α (percentage of spontaneous cell death) and β (percentage of cell death induced at a determined radiation dose). Higher β values in cytotoxic T-lymphocytes (CD8) and bone cells (B-lymphocytes) were observed in patients with low bowel toxicity (hazard ratio (HR) = 0.96, p = 0.002 for B-cells); low rectal toxicity (HR = 0.96, p = 0.020; HR = 0.93, p = 0.05 for B and CD8 subpopulations respectively); low urinary toxicity (HR = 0.93, p = 0.003 for B-cells) and low sexual toxicity (HR = 0.93, p = 0.010 for CD8-cells). Conclusions: Radiation-induced CD8 T-lymphocytes and, for the first time, B-lymphocytes apoptosis can predict differences in late toxicity in cervical cancer patients.en_US
dc.languageengen_US
dc.publisher0955-3002-
dc.relation.ispartofInternational Journal of Radiation Biologyen_US
dc.sourceInternational Journal of Radiation Biology [ISSN 0955-3002], v. 87, p. 424-431en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherLate toxicityen_US
dc.subject.otherB-lymphocytesen_US
dc.subject.otherRadiotherapyen_US
dc.subject.otherCervical canceren_US
dc.subject.otherRadiation-induced apoptosisen_US
dc.titleRole of CD4 and CD8 T-lymphocytes, B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patientsen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.3109/09553002.2010.537433
dc.identifier.scopus79953779062-
dc.identifier.isi000289079800008
dc.contributor.authorscopusid24402677200-
dc.contributor.authorscopusid37077083600-
dc.contributor.authorscopusid7004374085-
dc.contributor.authorscopusid6507421079-
dc.contributor.authorscopusid48061308800-
dc.contributor.authorscopusid7003855087-
dc.description.lastpage431-
dc.description.firstpage424-
dc.relation.volume87-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid2045042
dc.contributor.daisngid465624
dc.contributor.daisngid591076
dc.contributor.daisngid1285881
dc.contributor.daisngid603384
dc.contributor.daisngid802813
dc.contributor.wosstandardWOS:Bordon, E
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Lara, PC
dc.contributor.wosstandardWOS:Pinar, B
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C
dc.contributor.wosstandardWOS:Lloret, M
dc.date.coverdateAbril 2011
dc.identifier.ulpgces
dc.description.sjr0,702
dc.description.jcr2,275
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameBordón Rodríguez, Elisa de los Reyes-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameLloret Sáez-Bravo, Marta-
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