Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/43484
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rubio Sánchez, Sara | en_US |
dc.contributor.author | Quintana Aguiar, José Martín | en_US |
dc.contributor.author | Eiroa, José L. | en_US |
dc.contributor.author | Triana, Jorge | en_US |
dc.contributor.author | Estévez Rosas, Francisco Jesús | en_US |
dc.contributor.other | Rubio, Sara | - |
dc.contributor.other | Quintana, Jose | - |
dc.contributor.other | Estevez, Francisco | - |
dc.contributor.other | Rubio Sánchez, Sara | - |
dc.date.accessioned | 2018-11-21T15:31:49Z | - |
dc.date.available | 2018-11-21T15:31:49Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.issn | 0143-3334 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/43484 | - |
dc.description.abstract | Flavonoids are polyphenolic compounds that are ubiquitously in plants and display a vast array of biological activities. Here we have studied the effect of the phenylbenzo-γ-pyrone-derivative quercetin 3-methyl ether tetracetate (QD), obtained by acetylation of the natural product quercetin 3-methyl ether, on cell viability of human leukemia HL-60 and U937 cell lines. The results show that QD was cytotoxic and induced G 2 –M phase cell cycle arrest on both cell lines and it was a potent apoptotic inducer on HL-60 cells. QD-induced apoptosis is (i) mediated by caspase activation, since it was prevented by the non-specific caspase inhibitor z-VAD-fmk, (ii) associated with cytochrome c release and (iii) triggered in Bcl-2 over-expressing U937 cells. The treatment of HL-60 and U937 cells with QD also induces the activation of the mitogen-activated protein kinases (MAPKs) pathway, including c-Jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases (ERK) 1/2. Inhibition of c-Jun N-terminal kinase by SP600125 and of p38 mitogen-activated protein kinase by SB203580 had no influence on QD-mediated apoptosis. In contrast, inhibition of ERK1/2 with the pharmacologic inhibitors U0126 or PD98059, together with QD, resulted in an important enhancement of apoptosis. Cells are sensitized to QD-mediated apoptosis after blocking ERK1/2, which suggests that inhibition of this pathway is a valuable strategy to increase the sensitivity of human leukemia HL-60 cells toward QD. | en_US |
dc.language | eng | en_US |
dc.publisher | 0143-3334 | - |
dc.relation | Nuevos Compuestos Antileucémicos | en_US |
dc.relation.ispartof | Carcinogenesis | en_US |
dc.source | Carcinogenesis [ISSN 0143-3334], v. 28, p. 2105-2113 | en_US |
dc.subject | 32 Ciencias médicas | en_US |
dc.subject.other | Activated Protein-Kinase | |
dc.subject.other | P38 Map Kinase | |
dc.subject.other | Induced Apoptosis | |
dc.subject.other | Cancer-Therapy | |
dc.subject.other | Molecular-Mechanisms | |
dc.subject.other | Converting Enzyme | |
dc.subject.other | Hl-60 Cells | |
dc.subject.other | Pathway | |
dc.subject.other | Bcl-2 | |
dc.subject.other | Caspases | |
dc.title | Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1093/carcin/bgm131 | en_US |
dc.identifier.scopus | 35148878657 | - |
dc.identifier.isi | 000250676400007 | - |
dcterms.isPartOf | Carcinogenesis | - |
dcterms.source | Carcinogenesis[ISSN 0143-3334],v. 28 (10), p. 2105-2113 | - |
dc.contributor.authorscopusid | 22635323400 | - |
dc.contributor.authorscopusid | 8681043500 | - |
dc.contributor.authorscopusid | 6507583429 | - |
dc.contributor.authorscopusid | 6602859915 | - |
dc.contributor.authorscopusid | 7003810011 | - |
dc.description.lastpage | 2113 | en_US |
dc.description.firstpage | 2105 | en_US |
dc.relation.volume | 28 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000250676400007 | - |
dc.contributor.daisngid | 4276242 | - |
dc.contributor.daisngid | 128315 | - |
dc.contributor.daisngid | 2831014 | - |
dc.contributor.daisngid | 1400733 | - |
dc.contributor.daisngid | 384944 | - |
dc.identifier.investigatorRID | K-4656-2013 | - |
dc.identifier.investigatorRID | K-5709-2014 | - |
dc.identifier.investigatorRID | K-5125-2014 | - |
dc.identifier.investigatorRID | No ID | - |
dc.contributor.wosstandard | WOS:Rubio, S | - |
dc.contributor.wosstandard | WOS:Quintana, J | - |
dc.contributor.wosstandard | WOS:Eiroa, JL | - |
dc.contributor.wosstandard | WOS:Triana, J | - |
dc.contributor.wosstandard | WOS:Estevez, F | - |
dc.date.coverdate | Octubre 2007 | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 5,406 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.project.principalinvestigator | Estévez Rosas, Francisco Jesús | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0001-7633-1285 | - |
crisitem.author.orcid | 0000-0001-8225-4538 | - |
crisitem.author.orcid | 0000-0002-4986-8332 | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Rubio Sánchez, Sara | - |
crisitem.author.fullName | Quintana Aguiar, José Martín | - |
crisitem.author.fullName | Eiroa Martínez,José Luis | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
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