Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/43346
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ruiz Reyes, Antonio | en_US |
dc.contributor.author | Muñoz Ojeda, María del Carmen | en_US |
dc.contributor.author | Molina Caballero, José Manuel | en_US |
dc.contributor.author | Hermosilla, C. | en_US |
dc.contributor.author | Rodríguez Guisado, Francisco | en_US |
dc.contributor.author | Andrada Borzollino, Marisa Ana | en_US |
dc.contributor.author | Martín Martel, Sergio | en_US |
dc.contributor.author | A.Guedes | en_US |
dc.contributor.author | Pérez, D. | en_US |
dc.contributor.author | Matos, L. | en_US |
dc.contributor.author | López González, Adassa María | en_US |
dc.contributor.author | Taubert, A. | en_US |
dc.date.accessioned | 2018-11-21T14:27:10Z | - |
dc.date.available | 2018-11-21T14:27:10Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.issn | 0921-4488 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/43346 | - |
dc.description.abstract | Coccidiosis caused by the apicomplexan protozoa Eimeria ninakohlyakimovae has a high impact on animal health and profitability of the goat industry worldwide. Primary E. ninakohlyakimovae infections induce clinical disease mainly in goat kids, as homologous re-infections are commonly under immunological control. Nevertheless, there is evidence of fatal acute E. ninakohlyakimovae challenge-infections to occur in goat kids. So far, the nature of the immune response promoting protection or failure in E. ninakohlyakimovae challenge-infected goat kids has not been investigated. Therefore, we here analyzed cellular immune responses and histopathological alterations in the gut mucosa of fatal E. ninakohlyakimovae challenge-infected goat kids. Overall, a severe eosinophilic enteritis was observed in affected animals. Hyperplasia of epithelial cells, hypertrophy of globet cells and marked hyperplasia of Peyer's patches and mesenteric lymph nodes draining affected areas were also relevant findings. The majority of goat kids suffering from acute E. ninakohlyakimovae challenge-infections showed severe diarrhoea and some of them even died within 11–16 days post challenge, indicating that the mechanisms of pathogenicity might be related to the first generation macromeronts. Interestingly, infiltration of eosinophils and, in less extent, of intraepithelial lymphocytes and neutrophils was observed even within degraded E. ninakohlyakimovae first generation macromeronts. The excessive immune response mounted against intracellular E. ninakohlyakimovae stages (sporozoites/meronts I) as measured by intestinal leucocyte infiltration might result in severe pro-inflammatory reactions and contribute to the fatal outcome of the challenge infection. | en_US |
dc.language | eng | en_US |
dc.publisher | 0921-4488 | |
dc.relation.ispartof | Small Ruminant Research | en_US |
dc.source | Small Ruminant Research [ISSN 0921-4488], v. 113(1), p. 258-266 | en_US |
dc.subject | 310907 Patología | en_US |
dc.subject.other | Eimeria ninakohlyakimovae | en_US |
dc.subject.other | Challenge infection | en_US |
dc.subject.other | Fatal coccidiosis | en_US |
dc.subject.other | Caprine | en_US |
dc.title | Primary infection of goats with Eimeria ninakohlyakimovae does not provide protective immunity against high challenge infections | en_US |
dc.type | info:eu-repo/semantics/Article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1016/j.smallrumres.2013.01.006 | |
dc.identifier.scopus | 84878367782 | - |
dc.identifier.isi | 000320493200040 | |
dc.contributor.authorscopusid | 57201387360 | - |
dc.contributor.authorscopusid | 57199669332 | - |
dc.contributor.authorscopusid | 55731962600 | - |
dc.contributor.authorscopusid | 6602143835 | - |
dc.contributor.authorscopusid | 21641919200 | - |
dc.contributor.authorscopusid | 6602991535 | - |
dc.contributor.authorscopusid | 55450160500 | - |
dc.contributor.authorscopusid | 55588729900 | - |
dc.contributor.authorscopusid | 36096860400 | - |
dc.contributor.authorscopusid | 37026514900 | - |
dc.contributor.authorscopusid | 54784854300 | - |
dc.contributor.authorscopusid | 6603706756 | - |
dc.description.lastpage | 266 | - |
dc.description.firstpage | 258 | - |
dc.relation.volume | 113 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 1497623 | |
dc.contributor.daisngid | 29395753 | |
dc.contributor.daisngid | 742292 | |
dc.contributor.daisngid | 319992 | |
dc.contributor.daisngid | 2263409 | |
dc.contributor.daisngid | 862879 | |
dc.contributor.daisngid | 9182232 | |
dc.contributor.daisngid | 6154644 | |
dc.contributor.daisngid | 3415357 | |
dc.contributor.daisngid | 3230112 | |
dc.contributor.daisngid | 5350027 | |
dc.contributor.daisngid | 384245 | |
dc.contributor.wosstandard | WOS:Ruiz, A | |
dc.contributor.wosstandard | WOS:Munoz, MC | |
dc.contributor.wosstandard | WOS:Molina, JM | |
dc.contributor.wosstandard | WOS:Hermosilla, C | |
dc.contributor.wosstandard | WOS:Rodriguez, F | |
dc.contributor.wosstandard | WOS:Andrada, M | |
dc.contributor.wosstandard | WOS:Martin, S | |
dc.contributor.wosstandard | WOS:Guedes, A | |
dc.contributor.wosstandard | WOS:Perez, D | |
dc.contributor.wosstandard | WOS:Matos, L | |
dc.contributor.wosstandard | WOS:Lopez, AM | |
dc.contributor.wosstandard | WOS:Taubert, A | |
dc.date.coverdate | Junio 2013 | |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 0,68 | |
dc.description.jcr | 1,099 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q2 | |
dc.description.scie | SCIE | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | GIR Parasitología, dermatologia y biopatologia veterinaria | - |
crisitem.author.dept | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.dept | GIR Parasitología, dermatologia y biopatologia veterinaria | - |
crisitem.author.dept | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.dept | GIR Parasitología, dermatologia y biopatologia veterinaria | - |
crisitem.author.dept | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina) | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.dept | GIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.orcid | 0000-0003-0668-5496 | - |
crisitem.author.orcid | 0000-0002-0203-5034 | - |
crisitem.author.orcid | 0000-0002-8338-2512 | - |
crisitem.author.orcid | 0000-0002-4968-5333 | - |
crisitem.author.orcid | 0000-0002-2411-9714 | - |
crisitem.author.orcid | 0000-0002-1757-6634 | - |
crisitem.author.orcid | 0000-0003-1877-8964 | - |
crisitem.author.parentorg | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.parentorg | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.parentorg | Departamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Ruiz Reyes, Antonio | - |
crisitem.author.fullName | Muñoz Ojeda, María Del Carmen | - |
crisitem.author.fullName | Molina Caballero, José Manuel | - |
crisitem.author.fullName | Rodríguez Guisado, Francisco | - |
crisitem.author.fullName | Andrada Borzollino, Marisa Ana | - |
crisitem.author.fullName | Martín Martel, Sergio | - |
crisitem.author.fullName | López González, Adassa María | - |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
11
checked on Dec 1, 2024
WEB OF SCIENCETM
Citations
9
checked on Nov 24, 2024
Page view(s)
109
checked on Jan 23, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.