Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43346
DC FieldValueLanguage
dc.contributor.authorRuiz Reyes, Antonioen_US
dc.contributor.authorMuñoz Ojeda, María del Carmenen_US
dc.contributor.authorMolina Caballero, José Manuelen_US
dc.contributor.authorHermosilla, C.en_US
dc.contributor.authorRodríguez Guisado, Franciscoen_US
dc.contributor.authorAndrada Borzollino, Marisa Anaen_US
dc.contributor.authorMartín Martel, Sergioen_US
dc.contributor.authorA.Guedesen_US
dc.contributor.authorPérez, D.en_US
dc.contributor.authorMatos, L.en_US
dc.contributor.authorLópez González, Adassa Maríaen_US
dc.contributor.authorTaubert, A.en_US
dc.date.accessioned2018-11-21T14:27:10Z-
dc.date.available2018-11-21T14:27:10Z-
dc.date.issued2013en_US
dc.identifier.issn0921-4488en_US
dc.identifier.urihttp://hdl.handle.net/10553/43346-
dc.description.abstractCoccidiosis caused by the apicomplexan protozoa Eimeria ninakohlyakimovae has a high impact on animal health and profitability of the goat industry worldwide. Primary E. ninakohlyakimovae infections induce clinical disease mainly in goat kids, as homologous re-infections are commonly under immunological control. Nevertheless, there is evidence of fatal acute E. ninakohlyakimovae challenge-infections to occur in goat kids. So far, the nature of the immune response promoting protection or failure in E. ninakohlyakimovae challenge-infected goat kids has not been investigated. Therefore, we here analyzed cellular immune responses and histopathological alterations in the gut mucosa of fatal E. ninakohlyakimovae challenge-infected goat kids. Overall, a severe eosinophilic enteritis was observed in affected animals. Hyperplasia of epithelial cells, hypertrophy of globet cells and marked hyperplasia of Peyer's patches and mesenteric lymph nodes draining affected areas were also relevant findings. The majority of goat kids suffering from acute E. ninakohlyakimovae challenge-infections showed severe diarrhoea and some of them even died within 11–16 days post challenge, indicating that the mechanisms of pathogenicity might be related to the first generation macromeronts. Interestingly, infiltration of eosinophils and, in less extent, of intraepithelial lymphocytes and neutrophils was observed even within degraded E. ninakohlyakimovae first generation macromeronts. The excessive immune response mounted against intracellular E. ninakohlyakimovae stages (sporozoites/meronts I) as measured by intestinal leucocyte infiltration might result in severe pro-inflammatory reactions and contribute to the fatal outcome of the challenge infection.en_US
dc.languageengen_US
dc.publisher0921-4488
dc.relation.ispartofSmall Ruminant Researchen_US
dc.sourceSmall Ruminant Research [ISSN 0921-4488], v. 113(1), p. 258-266en_US
dc.subject310907 Patologíaen_US
dc.subject.otherEimeria ninakohlyakimovaeen_US
dc.subject.otherChallenge infectionen_US
dc.subject.otherFatal coccidiosisen_US
dc.subject.otherCaprineen_US
dc.titlePrimary infection of goats with Eimeria ninakohlyakimovae does not provide protective immunity against high challenge infectionsen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.smallrumres.2013.01.006
dc.identifier.scopus84878367782-
dc.identifier.isi000320493200040
dc.contributor.authorscopusid57201387360-
dc.contributor.authorscopusid57199669332-
dc.contributor.authorscopusid55731962600-
dc.contributor.authorscopusid6602143835-
dc.contributor.authorscopusid21641919200-
dc.contributor.authorscopusid6602991535-
dc.contributor.authorscopusid55450160500-
dc.contributor.authorscopusid55588729900-
dc.contributor.authorscopusid36096860400-
dc.contributor.authorscopusid37026514900-
dc.contributor.authorscopusid54784854300-
dc.contributor.authorscopusid6603706756-
dc.description.lastpage266-
dc.description.firstpage258-
dc.relation.volume113-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1497623
dc.contributor.daisngid29395753
dc.contributor.daisngid742292
dc.contributor.daisngid319992
dc.contributor.daisngid2263409
dc.contributor.daisngid862879
dc.contributor.daisngid9182232
dc.contributor.daisngid6154644
dc.contributor.daisngid3415357
dc.contributor.daisngid3230112
dc.contributor.daisngid5350027
dc.contributor.daisngid384245
dc.contributor.wosstandardWOS:Ruiz, A
dc.contributor.wosstandardWOS:Munoz, MC
dc.contributor.wosstandardWOS:Molina, JM
dc.contributor.wosstandardWOS:Hermosilla, C
dc.contributor.wosstandardWOS:Rodriguez, F
dc.contributor.wosstandardWOS:Andrada, M
dc.contributor.wosstandardWOS:Martin, S
dc.contributor.wosstandardWOS:Guedes, A
dc.contributor.wosstandardWOS:Perez, D
dc.contributor.wosstandardWOS:Matos, L
dc.contributor.wosstandardWOS:Lopez, AM
dc.contributor.wosstandardWOS:Taubert, A
dc.date.coverdateJunio 2013
dc.identifier.ulpgces
dc.description.sjr0,68
dc.description.jcr1,099
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptParasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptParasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptParasitología, dermatologia y biopatologia veterinaria-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptEpidemiología y Medicina Preventiva Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptMorfología-
crisitem.author.deptHistología y Patología Veterinaria-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptMorfología-
crisitem.author.deptMedicina Veterinaria e Investigación Terapeútica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-0668-5496-
crisitem.author.orcid0000-0002-8338-2512-
crisitem.author.orcid0000-0002-4968-5333-
crisitem.author.orcid0000-0002-2411-9714-
crisitem.author.parentorgPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgPatología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRuiz Reyes, Antonio-
crisitem.author.fullNameMuñoz Ojeda, María Del Carmen-
crisitem.author.fullNameMolina Caballero, José Manuel-
crisitem.author.fullNameRodríguez Guisado, Francisco-
crisitem.author.fullNameAndrada Borzollino, Marisa Ana-
crisitem.author.fullNameMartín Martel, Sergio-
crisitem.author.fullNameLópez González, Adassa María-
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