Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43069
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dc.contributor.authorLara, Pedro C.en_US
dc.contributor.authorLloret, Martaen_US
dc.contributor.authorClavo, Bernardinoen_US
dc.contributor.authorApolinario, Rosa M.en_US
dc.contributor.authorHenríquez-Hernández, Luisen_US
dc.contributor.authorBordón, Elisaen_US
dc.contributor.authorFontes, Faustoen_US
dc.contributor.authorRey, Agustínen_US
dc.date.accessioned2018-11-21T12:21:47Z-
dc.date.available2018-11-21T12:21:47Z-
dc.date.issued2009en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/43069-
dc.description.abstractOxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair through down regulating Ku70/80 expression. Hypoxia induces drug resistance in clinical tumours, although the mechanism is not clearly elucidated. Vaults are ribonucleoprotein particles with a hollow barrel-like structure composed of three proteins: major vault protein (MVP), vault poly(ADP-ribose) polymerase, and telomerase associated protein-1 and small untranslated RNA. Over-expression of MVP has been associated with chemotherapy resistance. Also, it has been related to poor outcome in patients treated with radiotherapy alone. The aim of the present study was to assess the relation of Major Vault Protein expression and tumor hypoxia in clinical cervical tumors. MVP, p53 and angiogenesis, together with tumor oxygenation, were determined in forty-three consecutive patients suffering from localized cervix carcinoma. High MVP expression was related to severe hypoxia compared to low MVP expressing tumors (p = 0.022). Tumors over-expressing MVP also showed increased angiogenesis (p = 0.003). Besides it, in this study we show for the first time that severe tumor hypoxia is associated with high MVP expression in clinical cervical tumors. Up-regulation of MVP by hypoxia is of critical relevance as chemotherapy is currently a standard treatment for those patients. From our results it could be suggested that hypoxia not only induces increased genetic instability, oncogenic properties and metastatization, but through the correlation observed with MVP expression, another pathway of chemo and radiation resistance could be developed. © 2009 Lara et al; licensee BioMed Central Ltd.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.sourceRadiation Oncology,v. 4 (29)en_US
dc.subject320713 Oncologíaen_US
dc.subject320111 Radiologíaen_US
dc.subject.otherTumor hypoxiaen_US
dc.subject.otherMVPen_US
dc.subject.otherMajor Vault Proteinen_US
dc.titleSevere hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expressionen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1748-717X-4-29en_US
dc.identifier.scopus2-s2.0-69049083600-
dc.contributor.authorscopusid7004374085-
dc.contributor.authorscopusid7003855087-
dc.contributor.authorscopusid57190093030-
dc.contributor.authorscopusid6602891555-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid24402677200-
dc.contributor.authorscopusid26039052100-
dc.contributor.authorscopusid7202860969-
dc.identifier.eissn1748-717X-
dc.identifier.issue29-
dc.relation.volume4en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateAgosto 2009en_US
dc.identifier.ulpgces
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptMedio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-2522-1064-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameClavo Varas, Bernardino-
crisitem.author.fullNameApolinario Hidalgo, Rosa María-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameBordón Rodríguez, Elisa de los Reyes-
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