Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43064
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dc.contributor.authorSaavedra, Maite M.
dc.contributor.authorHenríquez-Hernández, Luis Alberto
dc.contributor.authorLara, Pedro C.
dc.contributor.authorPinar, Beatriz
dc.contributor.authorRodríguez-Gallego, Carlos
dc.contributor.authorLloret, Marta
dc.date.accessioned2018-11-21T12:19:22Z-
dc.date.available2018-11-21T12:19:22Z-
dc.date.issued2010
dc.identifier.issn0449-3060
dc.identifier.urihttp://hdl.handle.net/10553/43064-
dc.description.abstractHead and neck cancer is treated mainly with surgery and radiotherapy. Xerostomia and mucositis are common adverse effects of radiation therapy. One of the strategies aimed at decreasing radiation toxicity is the use of radioprotective agents, such as amifostine. We previously reported that radio induced apoptosis of peripheral blood lymphocytes was statistically associated with normal tissue toxicity in the form of severe xerostomia. The aim of the present study was to explore the effects of amifostine on the radiation-induced apoptosis of peripheral blood lymphocytes from patients suffering head and neck cancer. Eighteen consecutive patients with squamous cell carcinoma of the head and neck were included in the study. Peripheral blood lymphocytes were isolated before and after the treatment with amifostine. Then, cells were irradiated at 0, 1, 2 and 8 Gy during 24 hours. Apoptosis was measured by flow cytometry using annexin V/propidium iodide. As expected, radio-induced apoptosis values fitted to a semi logarithmic equation as follows: RIA = beta In(Gy) + alpha. The administration of amifostine prior to radiation therapy modulates radio-induced apoptosis of peripheral blood lymphocytes: 13.68 vs. 13.37 (P = 0.027), 19.11 vs. 17.64 (P = 0.001) and 30.70 vs. 28.84 (P = 0.001), before and after the administration of the drug for 1, 2 and 8 Gy respectively, alpha and beta decreased significantly after the administration of the drug: 13.58 vs. 12.99 (P = 0.009) and 8.21 vs. 7.53 (P = 0.017), respectively. Our results provide new information about the biological actions of amifostine in vivo.
dc.publisher0449-3060
dc.relation.ispartofJournal of Radiation Research
dc.sourceJournal of Radiation Research[ISSN 0449-3060],v. 51, p. 603-607
dc.subject.otherCell-Cycle Progression
dc.subject.otherClinical Toxicity
dc.subject.otherGene-Expression
dc.subject.otherRadiation
dc.subject.otherRadiotherapy
dc.subject.otherWr-1065
dc.subject.otherDna
dc.subject.otherRadioprotector
dc.subject.otherXerostomia
dc.subject.otherPrediction
dc.titleAmifostine modulates radio-induced apoptosis of peripheral blood lymphocytes in head and neck cancer patients
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1269/jrr.10030
dc.identifier.scopus77958593707-
dc.identifier.isi000283004400014
dc.contributor.authorscopusid37075804700
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid7004374085
dc.contributor.authorscopusid6507421079
dc.contributor.authorscopusid6602114379
dc.contributor.authorscopusid7003855087
dc.description.lastpage607
dc.description.firstpage603
dc.relation.volume51
dc.type2Artículoes
dc.contributor.daisngid33722043
dc.contributor.daisngid465624
dc.contributor.daisngid591076
dc.contributor.daisngid1285881
dc.contributor.daisngid603384
dc.contributor.daisngid802813
dc.contributor.wosstandardWOS:Saavedra, MM
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA
dc.contributor.wosstandardWOS:Lara, PC
dc.contributor.wosstandardWOS:Pinar, B
dc.contributor.wosstandardWOS:Rodriguez-Gallego, C
dc.contributor.wosstandardWOS:Lloret, M
dc.date.coverdateNoviembre 2010
dc.identifier.ulpgces
dc.description.jcr2,007
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-4344-8644-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameRodríguez Gallego, José Carlos-
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