Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43061
Título: BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy
Autores/as: Henríquez-Hernández, Luis Alberto 
Lloret, Marta
Pinar, Beatriz
Bordón, Elisa 
Rey, Agustín
Lubrano, Amina
Lara, Pedro Carlos
Palabras clave: Major Vault Protein
Adverse Prognostic-Factor
Squamous-Cell Carcinoma
Double-Strand Breaks
End-Joining Pathway, et al.
Fecha de publicación: 2011
Editor/a: 0090-8258
Publicación seriada: Gynecologic Oncology 
Resumen: Objectives. To investigate whether BCL-2 expression would improve MVP/IGF-1R prediction of clinical outcome in cervix carcinoma patients treated by radiochemotherapy, and suggest possible mechanisms behind this effect.Methods. Fifty consecutive patients, who achieved complete response to treatment, from a whole series of 60 cases suffering from non-metastatic localized cervical carcinoma, were prospectively included in this study from July 1999 to December 2003. Follow-up was closed in January 2011. All patients received pelvic radiation (45-64.80 Gy in 1.8-2 Gy fractions) with concomitant cisplatin at 40 mg/m2/week closes followed by brachytherapy. Oncoprotein expression was studied by immunohistochemistry in paraffin-embedded tumour tissue.Results. No relation was found between BCL-2 and clinicopathological variables. High MVP/IGF-1R/BCL-2 tumour expression was strongly related to poor local and regional disease-free survival (P < 0.0001), distant disease-free survival (P= 0.010), disease-free survival (P < 0.0001), and cause-specific survival (P < 0.0001). NHEJ repair protein Ku70/80 expression was significantly repressed in tumours overexpressing all three oncoproteins (P= 0.047). No differences were observed in proliferation (Ki67 expression) or P53 alteration.Conclusions. BCL-2, MVP, and IGF-1R overexpression were related to poorer clinical outcome in cervical cancer patients who achieved clinical complete response to radiochemotherapy. The NHEJ repair protein Ku70/80 expression could be involved in the regulation of these oncoproteins. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10553/43061
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2011.05.037
Fuente: Gynecologic Oncology[ISSN 0090-8258],v. 122, p. 585-589
Colección:Artículos
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