Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/43060
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Valenciano, Almudena | en_US |
dc.contributor.author | Henríquez-Hernández, Luis Alberto | en_US |
dc.contributor.author | Moreno, Mercedes | en_US |
dc.contributor.author | Lloret, Marta | en_US |
dc.contributor.author | Lara, Pedro Carlos | en_US |
dc.date.accessioned | 2018-11-21T12:18:18Z | - |
dc.date.available | 2018-11-21T12:18:18Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.issn | 1936-5233 | en_US |
dc.identifier.other | WoS | - |
dc.identifier.uri | http://hdl.handle.net/10553/43060 | - |
dc.description.abstract | Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation. © 2012 Neoplasia Press, Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.relation | FIS 1035/98 | en_US |
dc.relation | 0855/01 | en_US |
dc.relation.ispartof | Translational Oncology | en_US |
dc.source | Translational Oncology [ISSN 1936-5233],v. 5(1), p. 1-9 | en_US |
dc.subject | 320101 Oncología | en_US |
dc.subject | 3208 Farmacodinámica | en_US |
dc.subject.other | Growth-Factor-I | en_US |
dc.subject.other | Squamous-Cell Carcinoma | en_US |
dc.subject.other | Strand-Break Repair | en_US |
dc.subject.other | Lung-Cancer Cells | en_US |
dc.subject.other | Annexin-Ii | en_US |
dc.subject.other | Prognostic-Significance | en_US |
dc.subject.other | Insulin-Receptor | en_US |
dc.subject.other | Dna-Damage | en_US |
dc.subject.other | Kinase | en_US |
dc.subject.other | Expression | en_US |
dc.title | Role of IGF-1 receptor in radiation response | en_US |
dc.type | info:eu-repo/semantics/review | en_US |
dc.type | review | en_US |
dc.identifier.doi | 10.1593/tlo.11265 | en_US |
dc.identifier.scopus | 84856006155 | - |
dc.identifier.isi | 000304817600001 | - |
dc.contributor.authorscopusid | 54904204300 | - |
dc.contributor.authorscopusid | 15829708200 | - |
dc.contributor.authorscopusid | 56328294100 | - |
dc.contributor.authorscopusid | 7003855087 | - |
dc.contributor.authorscopusid | 7004374085 | - |
dc.description.lastpage | 9 | en_US |
dc.identifier.issue | 1 | - |
dc.description.firstpage | 1 | en_US |
dc.relation.volume | 5 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Reseña | en_US |
dc.contributor.daisngid | 4100074 | - |
dc.contributor.daisngid | 465624 | - |
dc.contributor.daisngid | 3955607 | - |
dc.contributor.daisngid | 802813 | - |
dc.contributor.daisngid | 591076 | - |
dc.description.numberofpages | 9 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Valenciano, A | - |
dc.contributor.wosstandard | WOS:Henriquez-Hernandez, LA | - |
dc.contributor.wosstandard | WOS:Moreno, M | - |
dc.contributor.wosstandard | WOS:Lloret, M | - |
dc.contributor.wosstandard | WOS:Lara, PC | - |
dc.date.coverdate | Enero 2012 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 1,423 | |
dc.description.sjrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Con texto completo | - |
item.grantfulltext | open | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0003-3237-0316 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Henríquez Hernández, Luis Alberto | - |
crisitem.author.fullName | Lloret Sáez-Bravo, Marta | - |
Appears in Collections: | Reseña |
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