Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43060
Title: Role of IGF-1 receptor in radiation response
Authors: Valenciano, Almudena
Henríquez-Hernández, Luis Alberto 
Moreno, Mercedes
Lloret, Marta 
Lara, Pedro Carlos
UNESCO Clasification: 320101 Oncología
3208 Farmacodinámica
Keywords: Growth-Factor-I
Squamous-Cell Carcinoma
Strand-Break Repair
Lung-Cancer Cells
Annexin-Ii, et al
Issue Date: 2012
Project: FIS 1035/98
0855/01
Journal: Translational Oncology 
Abstract: Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation. © 2012 Neoplasia Press, Inc. All rights reserved.
URI: http://hdl.handle.net/10553/43060
ISSN: 1936-5233
DOI: 10.1593/tlo.11265
Source: Translational Oncology [ISSN 1936-5233],v. 5(1), p. 1-9
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