|Title:||Role of IGF-1 receptor in radiation response||Authors:||Valenciano, Almudena
Henríquez-Hernández, Luis Alberto
Lara, Pedro Carlos
|Issue Date:||2012||Journal:||Translational Oncology||Abstract:||Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation. © 2012 Neoplasia Press, Inc. All rights reserved.||URI:||http://hdl.handle.net/10553/43060||DOI:||10.1593/tlo.11265||Source:||Translational Oncology,v. 5, p. 1-9|
|Appears in Collections:||Reseña|
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