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Title: New biological markers in the decision of treatment of head and neck cancer patients
Authors: Valenciano, A.
Henríquez-Hernández, L. A. 
Lloret, M.
Pinar, B.
Lara, P. C.
Keywords: Squamous-Cell Carcinoma
Locally Advanced Head
Hyperfractionated Radical Radiotherapy
Single-Nucleotide Polymorphisms
Normal Tissue Toxicity
Major Vault Protein
Igf-1R Expression
Postoperative Irradiation
Nasopharyngeal Carcinoma
Issue Date: 2014
Publisher: 1699-048X
Journal: Clinical and Translational Oncology 
Abstract: Head and neck squamous cell carcinoma is the sixth most common cancer type worldwide. Also the 5-year survival rate of less than 50 % seems to be lower than other cancer types. There are some reasons behind this high mortality rate; one of them is the lack of knowledge about the biology and genomic instability behind the carcinogenic processes. These biological features could condition the failure of frontline treatment, in which case rescue treatment should be used, representing an overtreatment for the patients. For years many biological factors have been tested as prognostic and predictive factors in relation to treatment with a modest success. To find appropriate tests which could be used in the context of the individualized treatment decision, we have reviewed new biological markers, not only in tumor tissue, but also in normal tissue from head and neck carcinoma patients.
ISSN: 1699-048X
DOI: 10.1007/s12094-014-1193-7
Source: Clinical and Translational Oncology[ISSN 1699-048X],v. 16, p. 849-858
Appears in Collections:Reseña
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