Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43031
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dc.contributor.authorHenríquez-Hernández, Luis A.
dc.contributor.authorLuzardo, Octavio P.
dc.contributor.authorZumbado, Manuel
dc.contributor.authorCamacho, Maria
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorÁlvarez-León, Eva E.
dc.contributor.authorBoada, Luis D.
dc.contributor.otherZumbado, Manuel
dc.contributor.otherDominguez-Boada, Luis
dc.contributor.otherCAMACHO, MARIA
dc.contributor.otherHenriquez-Hernandez, Luis Alberto
dc.contributor.otherSerra-Majem, Lluis
dc.date.accessioned2018-11-21T12:10:44Z-
dc.date.available2018-11-21T12:10:44Z-
dc.date.issued2014
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10553/43031-
dc.description.abstract© 2014 Elsevier Inc.Background: Epidemiological studies have reported significant associations between exposure to persistent organic pollutants (POPs) and increased blood pressure (BP). Environmental exposure to POPs, mainly organochlorine pesticides, is of concern to the population of the Canary Islands, who display a high prevalence of diseases associated with hypertension such as metabolic syndrome, obesity and cardiovascular disease. Objective: We performed this population-based study in a representative population sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as hypertension risk factors. Methods: BP and several other well-known factors related to hypertension (gender, age, smoking, BMI, and total lipids) were recorded in 428 adult participants from the Canary Islands Nutritional Survey. In total, 28 POPs (including 18 polychlorinated biphenyl (PCB) congeners and 10 organochlorine pesticides and metabolites) were measured in the serum of the population enrolled in this survey. Results: In total, 167 subjects (39%) demonstrated hypertension or used antihypertensive medication. We observed a positive association between systolic and diastolic BP and p,p'-DDE (r=0.222; p<0.001, and r=0.123; p=0.015, respectively). Conversely, an inverse association between systolic BP and aldrin was observed (r=-0.120; p=0.017). After adjusting for known confounders, only aldrin was inversely related to hypertension risk [OR: 0.28 (95% CI: 0.09-0.92); p=0.037]. After excluding subjects undergoing anti-hypertensive treatment, we also observed that aldrin was inversely associated with systolic BP in multivariate analyses, especially in men [OR: 0.126 (95% CI: 0.021-0.763); p=0.024]. Conclusion: Although it has been postulated that background POPs exposure may play a relevant role on elevated BP, we did not observed increased hypertension risk in relation to serum POPs in this cross-sectional study. Conversely, the cyclodiene pesticide aldrin was negatively associated with hypertension, suggesting that cyclodienes could exert an effect opposite of the DDT metabolites. These findings agree with other previous works indicating that POPs may induce divergent actions on BP and suggest that the direction of the association between BP and POPs could be dependent on the chemical structure as well as concentration of the evaluated POP. Prospective studies are needed to clarify the effect exerted by POPs on BP.
dc.publisher0013-9351
dc.relation.ispartofEnvironmental research (New York, N.Y. Print)
dc.sourceEnvironmental Research[ISSN 0013-9351],v. 135, p. 48-54
dc.titleBlood pressure in relation to contamination by polychlorobiphenyls and organochlorine pesticides: Results from a population-based study in the Canary Islands (Spain)
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1016/j.envres.2014.05.036
dc.identifier.scopus84907817687-
dc.identifier.isi000346622800008
dcterms.isPartOfEnvironmental Research
dcterms.sourceEnvironmental Research[ISSN 0013-9351],v. 135, p. 48-54
dc.contributor.authorscopusid15829708200
dc.contributor.authorscopusid6507534124
dc.contributor.authorscopusid6603459604
dc.contributor.authorscopusid34067495700
dc.contributor.authorscopusid35596972100
dc.contributor.authorscopusid6603324897
dc.contributor.authorscopusid6603916807
dc.description.lastpage54
dc.description.firstpage48
dc.relation.volume135
dc.type2Artículoes
dc.identifier.wosWOS:000346622800008
dc.contributor.daisngid465624
dc.contributor.daisngid418704
dc.contributor.daisngid418822
dc.contributor.daisngid711282
dc.contributor.daisngid28836
dc.contributor.daisngid1848250
dc.contributor.daisngid697526
dc.identifier.investigatorRIDB-4495-2010
dc.identifier.investigatorRIDL-5577-2015
dc.identifier.investigatorRIDH-5085-2015
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.date.coverdateNoviembre 2014
dc.identifier.ulpgces
dc.description.sjr1,787
dc.description.jcr4,373
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0003-2891-1474-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameCamacho Rodríguez, María De Los Ángeles-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.author.fullNameDomínguez Boada, Luis María-
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