Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43022
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dc.contributor.authorLuzardo, Octavio P.en_US
dc.contributor.authorAlmeida-González, Mairaen_US
dc.contributor.authorRuiz Suarez, Norbertoen_US
dc.contributor.authorZumbado, Manuelen_US
dc.contributor.authorHenríquez-Hernández, Luis A.en_US
dc.contributor.authorMeilán, María Joséen_US
dc.contributor.authorCamacho, Maríaen_US
dc.contributor.authorBoada, Luis D.en_US
dc.date.accessioned2018-11-21T12:08:17Z-
dc.date.available2018-11-21T12:08:17Z-
dc.date.issued2015en_US
dc.identifier.issn1355-0306en_US
dc.identifier.urihttp://hdl.handle.net/10553/43022-
dc.description.abstractPesticides are frequently responsible for human poisoning and often the information on the involved substance is lacking. The great variety of pesticides that could be responsible for intoxication makes necessary the development of powerful and versatile analytical methodologies, which allows the identification of the unknown toxic substance. Here we developed a methodology for simultaneous identification and quantification in human blood of 109 highly toxic pesticides. The application of this analytical scheme would help in minimizing the cost of this type of chemical identification, maximizing the chances of identifying the pesticide involved. In the methodology that we present here, we use a liquid–liquid extraction, followed by one single purification step, and quantitation of analytes by a combination of liquid and gas chromatography, both coupled to triple quadrupole mass spectrometry, which is operated in the mode of multiple reaction monitoring. The methodology has been fully validated, and its applicability has been demonstrated in two recent cases involving one self-poisoning fatality and one non-fatal homicidal attempt.en_US
dc.languageengen_US
dc.publisher1355-0306-
dc.relation.ispartofScience and Justice - Journal of the Forensic Science Societyen_US
dc.sourceScience and Justice - Journal of the Forensic Science Society [ISSN 1355-0306], v. 55, p. 307-315, (2015)en_US
dc.subject32 Ciencias médicasen_US
dc.subject3214 Toxicologíaen_US
dc.subject.otherForensic scienceen_US
dc.subject.otherPesticide poisoningen_US
dc.subject.otherForensic toxicologyen_US
dc.subject.otherMultiresidueen_US
dc.subject.otherGC–MS/MSen_US
dc.subject.otherLC–MS/MSen_US
dc.titleValidated analytical methodology for the simultaneous determination of a wide range of pesticides in human blood using GC-MS/MS and LC-ESI/MS/MS and its application in two poisoning casesen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.scijus.2015.04.007en_US
dc.identifier.pmid26385712-
dc.identifier.scopus84941742978-
dc.identifier.isi000362137300004-
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dc.contributor.authorscopusid6507534124-
dc.contributor.authorscopusid36450107800-
dc.contributor.authorscopusid55376446600-
dc.contributor.authorscopusid6603459604-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid56622990300-
dc.contributor.authorscopusid34067495700-
dc.contributor.authorscopusid6603916807-
dc.description.lastpage315en_US
dc.identifier.issue5-
dc.description.firstpage307en_US
dc.relation.volume55en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid418704-
dc.contributor.daisngid1343269-
dc.contributor.daisngid2444587-
dc.contributor.daisngid418822-
dc.contributor.daisngid465624-
dc.contributor.daisngid11444767-
dc.contributor.daisngid711282-
dc.contributor.daisngid1656886-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Luzardo, OP-
dc.contributor.wosstandardWOS:Almeida-Gonzalez, M-
dc.contributor.wosstandardWOS:Ruiz-Suarez, N-
dc.contributor.wosstandardWOS:Zumbado, M-
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA-
dc.contributor.wosstandardWOS:Meilan, MJ-
dc.contributor.wosstandardWOS:Camacho, M-
dc.contributor.wosstandardWOS:Boada, LD-
dc.date.coverdateSeptiembre 2015en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr0,917
dc.description.jcr1,959
dc.description.sjrqQ2
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.orcid0000-0003-2410-4659-
crisitem.author.orcid0000-0003-3610-8403-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0003-2891-1474-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
crisitem.author.fullNameAlmeida González, Maira Del Pino-
crisitem.author.fullNameRuiz Suarez,Norberto-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNameCamacho Rodríguez, María De Los Ángeles-
crisitem.author.fullNameDomínguez Boada, Luis María-
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