Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43008
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dc.contributor.authorGarcía-Arencibia, Moisésen_US
dc.contributor.authorGarcía, Concepciónen_US
dc.contributor.authorKurz, Alexanderen_US
dc.contributor.authorRodríguez-Navarro, José A.en_US
dc.contributor.authorGispert-Sánchez, Suzanaen_US
dc.contributor.authorMena, María A.en_US
dc.contributor.authorAuburger, Georgen_US
dc.contributor.authorDe Yébenes, Justo Garcíaen_US
dc.contributor.authorFernández-Ruiz, Javieren_US
dc.date.accessioned2018-11-21T12:04:11Z-
dc.date.available2018-11-21T12:04:11Z-
dc.date.issued2009en_US
dc.identifier.isbn9783211926598-
dc.identifier.issn0303-6995en_US
dc.identifier.urihttp://hdl.handle.net/10553/43008-
dc.description.abstractThis study was designed to examine the type of changes experienced by the CB1 receptor, a key element of the cannabinoid signaling system, in the basal ganglia of different mouse mutants generated by deletion of specific genes associated with the development of Parkinson's disease in humans [PARK1 (alpha-synuclein), PARK2 (parkin) or PARK6 (PINK1)]. We observed that CB1 receptor-mRNA levels were significantly reduced in the caudate-putamen in the three models under examination when animals were analyzed at early phases (< or = 12 months of age). This decrease was, in general, associated with a reduction in CB1 receptor binding in the substantia nigra and the globus pallidus, particularly in the case of alpha-synuclein-deficient mice. By contrast, both parameters, mRNA levels and binding for the CB1 receptor, showed an elevation in the same areas when animals were analyzed at older ages, mainly in the case of the CB1 receptor binding in the substantia nigra. In summary, our data revealed the existence of a biphasic response for CB1 receptors, with losses at early phases, when dopaminergic dysfunction is possibly the major event that takes place, followed by upregulatory responses at advanced phases characterized by the occurrence of evident nigrostriatal pathology including neuronal death in some casesen_US
dc.languageengen_US
dc.publisher0303-6995-
dc.relation.ispartofJournal of Neural Transmission, Supplementen_US
dc.sourceJournal of Neural Transmission, Supplementa [ISSN 0303-6995], p. 269-275en_US
dc.subject320507 Neurologíaen_US
dc.subject.otherParkinsonismen_US
dc.subject.otherPINK1en_US
dc.subject.otherCannabinoid signaling systemen_US
dc.titleCannabinoid CB<inf>1</inf> receptors are early DownRegulated followed by a further UpRegulation in the basal Ganglia of mice with deletion of specific park genesen_US
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.doi10.1007/978-3-211-92660-4-22en_US
dc.identifier.scopus75349085227-
dc.contributor.authorscopusid15821889300-
dc.contributor.authorscopusid7401486282-
dc.contributor.authorscopusid7101885394-
dc.contributor.authorscopusid8674223500-
dc.contributor.authorscopusid7801629409-
dc.contributor.authorscopusid7101747348-
dc.contributor.authorscopusid7005458571-
dc.contributor.authorscopusid56741932500-
dc.contributor.authorscopusid7006533053-
dc.description.lastpage275-
dc.description.firstpage269-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.jcr2,525
dc.description.jcrqQ3
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR TIDES: Investigación en Turismo y Transporte-
crisitem.author.deptIU de Turismo y Desarrollo Económico Sostenible-
crisitem.author.deptDepartamento de Análisis Económico Aplicado-
crisitem.author.orcid0000-0002-1618-4487-
crisitem.author.orcid0000-0002-0591-1298-
crisitem.author.parentorgIU de Turismo y Desarrollo Económico Sostenible-
crisitem.author.fullNameGarcía Arencibia, Moisés-
crisitem.author.fullNameRomán García, Concepción-
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