Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/43008
DC Field | Value | Language |
---|---|---|
dc.contributor.author | García-Arencibia, Moisés | en_US |
dc.contributor.author | García, Concepción | en_US |
dc.contributor.author | Kurz, Alexander | en_US |
dc.contributor.author | Rodríguez-Navarro, José A. | en_US |
dc.contributor.author | Gispert-Sánchez, Suzana | en_US |
dc.contributor.author | Mena, María A. | en_US |
dc.contributor.author | Auburger, Georg | en_US |
dc.contributor.author | De Yébenes, Justo García | en_US |
dc.contributor.author | Fernández-Ruiz, Javier | en_US |
dc.date.accessioned | 2018-11-21T12:04:11Z | - |
dc.date.available | 2018-11-21T12:04:11Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.isbn | 9783211926598 | - |
dc.identifier.issn | 0303-6995 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/43008 | - |
dc.description.abstract | This study was designed to examine the type of changes experienced by the CB1 receptor, a key element of the cannabinoid signaling system, in the basal ganglia of different mouse mutants generated by deletion of specific genes associated with the development of Parkinson's disease in humans [PARK1 (alpha-synuclein), PARK2 (parkin) or PARK6 (PINK1)]. We observed that CB1 receptor-mRNA levels were significantly reduced in the caudate-putamen in the three models under examination when animals were analyzed at early phases (< or = 12 months of age). This decrease was, in general, associated with a reduction in CB1 receptor binding in the substantia nigra and the globus pallidus, particularly in the case of alpha-synuclein-deficient mice. By contrast, both parameters, mRNA levels and binding for the CB1 receptor, showed an elevation in the same areas when animals were analyzed at older ages, mainly in the case of the CB1 receptor binding in the substantia nigra. In summary, our data revealed the existence of a biphasic response for CB1 receptors, with losses at early phases, when dopaminergic dysfunction is possibly the major event that takes place, followed by upregulatory responses at advanced phases characterized by the occurrence of evident nigrostriatal pathology including neuronal death in some cases | en_US |
dc.language | eng | en_US |
dc.publisher | 0303-6995 | - |
dc.relation.ispartof | Journal of Neural Transmission, Supplement | en_US |
dc.source | Journal of Neural Transmission, Supplementa [ISSN 0303-6995], p. 269-275 | en_US |
dc.subject | 320507 Neurología | en_US |
dc.subject.other | Parkinsonism | en_US |
dc.subject.other | PINK1 | en_US |
dc.subject.other | Cannabinoid signaling system | en_US |
dc.title | Cannabinoid CB<inf>1</inf> receptors are early DownRegulated followed by a further UpRegulation in the basal Ganglia of mice with deletion of specific park genes | en_US |
dc.type | info:eu-repo/semantics/article | es |
dc.type | Article | es |
dc.identifier.doi | 10.1007/978-3-211-92660-4-22 | en_US |
dc.identifier.scopus | 75349085227 | - |
dc.contributor.authorscopusid | 15821889300 | - |
dc.contributor.authorscopusid | 7401486282 | - |
dc.contributor.authorscopusid | 7101885394 | - |
dc.contributor.authorscopusid | 8674223500 | - |
dc.contributor.authorscopusid | 7801629409 | - |
dc.contributor.authorscopusid | 7101747348 | - |
dc.contributor.authorscopusid | 7005458571 | - |
dc.contributor.authorscopusid | 56741932500 | - |
dc.contributor.authorscopusid | 7006533053 | - |
dc.description.lastpage | 275 | - |
dc.description.firstpage | 269 | - |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 2,525 | |
dc.description.jcrq | Q3 | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR TIDES: Investigación en Turismo y Transporte | - |
crisitem.author.dept | IU de Turismo y Desarrollo Económico Sostenible | - |
crisitem.author.dept | Departamento de Análisis Económico Aplicado | - |
crisitem.author.orcid | 0000-0002-1618-4487 | - |
crisitem.author.orcid | 0000-0002-0591-1298 | - |
crisitem.author.parentorg | IU de Turismo y Desarrollo Económico Sostenible | - |
crisitem.author.fullName | García Arencibia, Moisés | - |
crisitem.author.fullName | Román García, Concepción | - |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
40
checked on Dec 1, 2024
Page view(s)
103
checked on Nov 23, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.