Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/43005
Title: Autophagy, a guardian against neurodegeneration
Authors: García-Arencibia, Moisés 
Hochfeld, Warren E.
Toh, Pearl P.C.
Rubinsztein, David C.
UNESCO Clasification: 320507 Neurología
Keywords: Autophagy
Alzheimer disease
Neurodegeneration
Huntington disease
Issue Date: 2010
Publisher: 1084-9521
Journal: Seminars in Cell and Developmental Biology 
Abstract: Autophagy is an intracellular degradation process responsible for the clearance of most long-lived proteins and organelles. Cytoplasmic components are enclosed by double-membrane autophagosomes, which subsequently fuse with lysosomes for degradation. Autophagy dysfunction may contribute to the pathology of various neurodegenerative disorders, which manifest abnormal protein accumulation. As autophagy induction enhances the clearance of aggregate-prone intracytoplasmic proteins that cause neurodegeneration (like mutant huntingtin, tau and ataxin 3) and confers cytoprotective roles in cell and animal models, upregulating autophagy may be a tractable therapeutic strategy for diseases caused by such proteins. Here, we will review the molecular machinery of autophagy and its role in neurodegenerative diseases. Drugs and associated signalling pathways that may be targeted for pharmacological induction of autophagy will also be discussed.
URI: http://hdl.handle.net/10553/43005
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2010.02.008
WOS:000281350200006
Source: Seminars in Cell and Developmental Biology [ISSN 1084-9521], v. 21, p. 691-698
Appears in Collections:Reseña
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