Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/43002
Título: Regulation of mammalian autophagy in physiology and pathophysiology
Autores/as: Ravikumar, Brinda
Sarkar, Sovan
Davies, Janet E.
Futter, Marie
Garcia-Arencibia, Moises 
Green-Thompson, Zeyn W.
Jimenez-Sanchez, Maria
Korolchuk, Viktor I.
Lichtenberg, Maike
Luo, Shouqing
Massey, Dunecan C.O.
Menzies, Fiona M.
Moreau, Kevin
Narayanan, Usha
Renna, Maurizio
Siddiqi, Farah H.
Underwood, Benjamin R.
Winslow And, Ashley R.
Rubinsztein, David C.
Clasificación UNESCO: 32 Ciencias médicas
Fecha de publicación: 2010
Editor/a: 0031-9333
Publicación seriada: Physiological Reviews 
Resumen: (Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned structures, which engulf portions of cytoplasm. The resulting autophagosomes ultimately fuse with lysosomes, where their contents are degraded. Although the term autophagy was first used in 1963, the field has witnessed dramatic growth in the last 5 years, partly as a consequence of the discovery of key components of its cellular machinery. In this review we focus on mammalian autophagy, and we give an overview of the understanding of its machinery and the signaling cascades that regulate it. As recent studies have also shown that autophagy is critical in a range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including neurodegeneration, lysosomal storage diseases, cancers, and Crohn's disease, we discuss the roles of autophagy in health and disease, while trying to critically evaluate if the coincidence between autophagy and these conditions is causal or an epiphenomenon. Finally, we consider the possibility of autophagy upregulation as a therapeutic approach for various conditions.
URI: http://hdl.handle.net/10553/43002
ISSN: 0031-9333
DOI: 10.1152/physrev.00030.2009
WOS:000283216100004
Fuente: Physiological Reviews [ISSN 0031-9333], v. 90, p. 1383-1435
Colección:Reseña
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