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Title: Regulation of mammalian autophagy in physiology and pathophysiology
Authors: Ravikumar, Brinda
Sarkar, Sovan
Davies, Janet E.
Futter, Marie
Garcia-Arencibia, Moises 
Green-Thompson, Zeyn W.
Jimenez-Sanchez, Maria
Korolchuk, Viktor I.
Lichtenberg, Maike
Luo, Shouqing
Massey, Dunecan C.O.
Menzies, Fiona M.
Moreau, Kevin
Narayanan, Usha
Renna, Maurizio
Siddiqi, Farah H.
Underwood, Benjamin R.
Winslow And, Ashley R.
Rubinsztein, David C.
UNESCO Clasification: 32 Ciencias médicas
Issue Date: 2010
Publisher: 0031-9333
Journal: Physiological Reviews 
Abstract: (Macro)autophagy is a bulk degradation process that mediates the clearance of long-lived proteins and organelles. Autophagy is initiated by double-membraned structures, which engulf portions of cytoplasm. The resulting autophagosomes ultimately fuse with lysosomes, where their contents are degraded. Although the term autophagy was first used in 1963, the field has witnessed dramatic growth in the last 5 years, partly as a consequence of the discovery of key components of its cellular machinery. In this review we focus on mammalian autophagy, and we give an overview of the understanding of its machinery and the signaling cascades that regulate it. As recent studies have also shown that autophagy is critical in a range of normal human physiological processes, and defective autophagy is associated with diverse diseases, including neurodegeneration, lysosomal storage diseases, cancers, and Crohn's disease, we discuss the roles of autophagy in health and disease, while trying to critically evaluate if the coincidence between autophagy and these conditions is causal or an epiphenomenon. Finally, we consider the possibility of autophagy upregulation as a therapeutic approach for various conditions.
ISSN: 0031-9333
DOI: 10.1152/physrev.00030.2009
Source: Physiological Reviews [ISSN 0031-9333], v. 90, p. 1383-1435
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